JNK

ADC Related

ADC Antibody ADC Cytotoxin ADC Linker ADCs Drug-Linker Conjugates for ADC
Angiogenesis

5-alpha Reductase ALK Bcr-Abl BTK EGFR FAK FLT3 HER-2 HIF Src Syk VDA VEGFR
Anti-infection

Antibiotic Arenavirus Bacterial CMV EBV Enterovirus Filovirus Fungal Gli HBV HCV HCV Protease HIV HSV Influenza Virus Parasite RABV Reverse Transcriptase RSV SARS-CoV TMV Virus Protease
Apoptosis

Apoptosis ASK Bcl-2 Caspase c-Myc c-RET Cytohesin DAPK Ferroptosis FKBP IAP Mdm2 p53 PD-1 PD-L1 PERK PKD Ras RIP kinase ROS Survivin Thymidylate Synthase TNF Receptor TNFa TRADD
Autophagy

Autophagy LRRK2 Mitophagy OGA ULK
Cell Cycle

Antifolate APC Aurora Kinase BMI-1 CDK Chk c-Myc Eukaryotic Initiation Factor G-quadruplex HDAC HSP Kinesin LIMK Mad2 Microtubule(Tubulin) Mps1 Nucleoside Antimetabolite/Analog Nur77 p21 PAK PERK PFKFB PLK PPAR Ras Rho ROCK SRPK TOPK Topoisomerase Wee1
Cytoskeletal Signaling

Arp2 3 Complex Bcr-Abl Cardiac Myosin Dynamin Gap Junction Protein HSP Integrin Kinesin Microtubule Associated MLCK Myosin PAK TACC3 Wntbeta-catenin
DNA Damage

ATM(ATR) CRISPR(Cas9) DNA alkylator DNA Stain DNA(RNA) Synthesis GAK HDAC HSP Nucleoside Antimetabolite(Analog) OGG1 p97 PARG PARP RAD51 RNR Sirtuin SMN Telomerase Topoisomerase
Endocrinology & Hormones

5-alpha Reductase ACE Adrenergic Receptor Androgen Receptor Aromatase Estrogenprogestogen Receptor Glucocorticoid Receptor GPR Mineralocorticoid Receptor RAAS THR TSH Receptor
Epigenetics

AMPK Aurora Kinase DNA Methyltransferase Epigenetic Reader Domain EZH1 2 HDAC HIF Histone Acetyltransferase Histone Demethylase Histone Methyltransferase JAK MAT MicroRNA MLL Pim PKC Protein Arginine Deiminase Sirtuin Small Interfering RNA (siRNA) SMYD

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JNK

JNK (c-Jun N-terminal kinase), a kinase subfamily belonging to the MAPK, is activated in response to various stress stimuli and possesses a wide variety of regulatory functions.Three isoforms of the serine/threonine protein kinase JNK family (JNK1, JNK2, and JNK3) exist. JNKs play a role in the development and progression of many pathologies, including cancer, inflammatory diseases, cardiovascular and metabolic disorders, and neurodegenerative diseases.

JNKs are triggered by a phosphorylation cascade that typically involves two different upstream kinases, the so-called MAP kinase kinase kinases (MAP3K, MKKK) and the MAP kinase kinases (MAP2K; MKK). This process is similar to that used to activate the other MAP kinases. JNKs are triggered by MKK4 and MKK7 at the MAP2K level; the former is a shared activator of the JNK and p38 MAP kinase signaling pathways. The JNK cascade is a component of a complicated signaling network since it crosses numerous other routes at different places.

JNK related products

Cat No.	Product Name	CAS No.	Product Description
V10399	AEG-3482	63735-71-7	AEG-3482 is a novel and potent antiapoptotic compound.
V51559	8-Hydroxy-efavirenz	205754-33-2	major metabolite of Efavirenz
V3735	AS601245	345987-15-7	AS601245 is an inhibitor of the JNK signaling pathway, it showed high JNK1/2/3 inhibition with IC50 of 150, 220, and 70 nM respectively.
V94568	AS601245 TFA	345987-16-8	AS601245 TFA is an orally active, selective, ATP-competitive JNK inhibitor with IC50 of 150, 220, and 70 nM for three human JNK isoforms (hJNK1, hJNK2, and hJNK3), respectively.
V98216	Autophagy inducer 5		Autophagy inducer 5 (compound 21o) is a potent MCF-7 inhibitor (IC50: 2 μM) and a potential breast cancer inhibitor.
V2665	BI-78D3	883065-90-5	BI-78D3 (also known as JNK Inhibitor X) is a novel, potent and competitive JNK inhibitor with IC50 of 280nM.
V96909	BSO-07		BSO-07 is a ROS/JNK activator with significant anticancer effects, with an IC50 of 24.81 μM against human breast cancer (BC) cells.
V2078	CC-401	395104-30-0	CC-401 (CC401) is a potent, specific, 2nd generation and ATP-competitive anthrapyrazolone c-Jun N terminal kinase (JNK) inhibitor with potential antineoplastic activity.
V2978	CC-401 HCl	1438391-30-0	CC-401 HCl (CC401 hydrochloride) is an anthrapyrazolone-based inhibitor of c-Jun N terminal kinase (JNK) with potential anticancer activity.
V2263	CC-90001	1403859-14-2	CC-90001 (CC90001; CC 90001) is a novel, potent and selective inhibitor of c-Jun N-terminal kinase (JNK) with potential anti-fibrotic activity.
V87071	CMX-8933	146877-90-9	CMX-8933 is an octapeptide fragment of the goldfish brain neurotrophic factor ependymin.
V19209	DB07268	929007-72-7	DB07268 is a potent and specific JNK1 inhibitor (antagonist) with IC50 of 9 nM.
V80005	DN-1289	3026597-15-6	DN-1289 is an orally bioactive, selective inhibitor targeting dileucine zipper kinase (DLK; IC50=17 nM) and leucine zipper-bearing kinase (LZK; IC50=40 nM).
V0474	DTP3	1809784-29-9	DTP3 (DTP-3) is a novel, potent and selective inhibitor of GADD45β/MKK7 ((growth arrest and DNA-damage-inducible β/mitogen-activated protein kinase kinase 7) with potential anticancer activity.
V22646	IQ-1S	23146-22-7	IQ-1S is a potent and selective c-Jun N-Terminal Kinase Inhibitor.
V51553	JIP-1 (153-163)	438567-88-5	peptide-based JNK inhibitor
V87072	JIP-1(153-163) TFA		JIP-1(153-163) TFA (TI-JIP TFA) is a peptide inhibitor of c-JNK.
V80447	JIP-1(153-163) TFA (T1-JIP TFA)		JIP-1(153-163) TFA (TI-JIP TFA) is a bioactive peptide inhibitor of c-JNK.
V80254	JNK-1-IN-2		JNK-1-IN-2 (Compound c6) is a JNK-1 inhibitor (IC50= 33.5 nM).
V97456	JNK-1-IN-3		JNK-1-IN-3 (compound 9e) is a JNK1 inhibitor that can downregulate JNK1 gene expression and inhibit its phosphorylated protein level, while reducing the expression of its downstream targets c-Jun and c-Fos in tumors and restoring p53 activity.