E3 Ligase Ligand-Linker Conjugates

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E3 Ligase Ligand-Linker Conjugates

E3 Ligase Ligand-Linker Conjugate, which is one part of Proteolysis Targeting Chimeric Molecules (PROTACs), incorporates a ligand for the E3 ubiquitin ligase and a linker.These conjugates can be used to create PROTACs that target proteins for ubiquitination and destruction after being coupled to the ligand for the target protein (for example, JQ1 for the BRD4 protein or Molibresib for the BET protein). Currently, a number of PROTACs that specifically target BET, the estrogen receptor (ER), the androgen receptor, etc. have been identified to demonstrate good biological activity.

E3 Ligase Ligand-Linker Conjugates related products

Cat No.	Product Name	CAS No.	Product Description
V84950	tDHU, acid	2377643-37-1
V84917	Thalidomide 4'-ether-PEG2-azide	2758431-90-0
V84551	Thalidomide 4'-oxyacetamide-C1-PEG3-C3-amine hydrochloride	2564466-93-7
V82483	Thalidomide-4-NH-PEG1-COO(t-Bu)	2140807-19-6	Thalidomide-4-NH-PEG1-COO(t-Bu) is a t-Bu modified Thalidomide, which could be utilized as Cereblon ligand to recruit CRBN protein.
V82490	Thalidomide-4-O-C2-NH2	390367-50-7	Thalidomide 4'-ether-alkylC2-amine is a synthetic E3 ligase (e.g. CRBN) ligand-linker conjugate, containing Thalidomide-based cereblon ligand and 1 linker, which may be utilized to prepare PROTAC molecules.
V82431	Thalidomide-4-O-CH2-COO(t-Bu)	1950635-36-5	Thalidomide-4-O-CH2-COO(t-Bu) is a t-Bu modified Thalidomide and is the final intermediate in the synthesis/preparation of Thalidomide-4-OH .
V82387	Thalidomide-5-NH-PEG1-NH2 hydrochloride	2863634-98-2	Thalidomide-5-NH-PEG1-NH2 HCl is a cereblon ligand based on Thalidomide that recruits CRBN protein.
V82376	Thalidomide-5-NH-PEG2-NH2 hydrochloride	2357110-58-6	Thalidomide-5-NH-PEG2-NH2 HCl is a Thalidomide based cereblon (E3 ligase) ligand that recruits CRBN protein.
V82388	Thalidomide-5-NH-PEG3-NH2 hydrochloride	2863635-01-0	Thalidomide-5-NH-PEG3-NH2 HCl is a Thalidomide based cereblon (E3 ligase) ligand that recruits CRBN protein.
V79143	Thalidomide-5-NH-PEG4-NH4 hydrochloride		Thalidomide-5-NH-PEG4-NH4 (HCl) is a synthetic compound containing Thalidomide.
V82382	Thalidomide-5-O-C2-NH2 hydrochloride	2694727-89-2	Thalidomide-5-O-C2-NH2 HCl is a Thalidomide based cereblon (E3 ligase) ligand that recruits CRBN protein.
V82392	Thalidomide-5-O-C3-NH2 hydrochloride	2694727-94-9	Thalidomide-5-O-C3-NH2 HCl is a Thalidomide based cereblon (E3 ligase) ligand that recruits CRBN protein.
V82394	Thalidomide-5-O-C4-NH2 hydrochloride	2694727-93-8	Thalidomide-5-O-C4-NH2 HCl is a cereblon ligand based on Thalidomide that recruits CRBN protein.
V82390	Thalidomide-5-O-C5-NH2 hydrochloride	2761385-94-6	Thalidomide-5-O-C5-NH2 HCl is a Thalidomide based cereblon (E3 ligase) ligand that recruits CRBN protein.
V82391	Thalidomide-5-O-C6-NH2 hydrochloride	2761398-05-2	Thalidomide-5-O-C6-NH2 HCl is a cereblon ligand based on Thalidomide that recruits CRBN protein.
V82384	Thalidomide-5-PEG2-NH2 hydrochloride	2761406-70-4	Thalidomide-5-PEG2-NH2 HCl is a Thalidomide based cereblon (E3 ligase) ligand that recruits CRBN protein.
V82367	Thalidomide-5-propoxyethanamine	2357107-60-7	Thalidomide-5-propoxyethanamine is a Thalidomide-based CRBN ligand used for CRBN protein recruitment.
V82365	Thalidomide-amido-PEG2-NH2	2380273-72-1	Thalidomide-amido-PEG2-NH2 is a synthetic E3 ligase (e.g. CRBN) ligand-linker conjugate, containing Thalidomide-based cereblon ligand and 1 linker, which may be utilized to prepare PROTAC molecules.
V82459	Thalidomide-amido-PEG2-NH2 hydrochloride	2380273-73-2	Thalidomide-amido-PEG2-NH2 HCl is a synthetic E3 ligase (e.g. CRBN) ligand-linker conjugate, containing Thalidomide-based cereblon ligand and 1 linker, which may be utilized to prepare PROTAC molecules.
V82427	Thalidomide-benzo	458151-34-3	Thalidomide-benzo is a Thalidomide-based cereblon (E3 ligase) ligand that recruits CRBN protein.