E3 Ligase Ligand-Linker Conjugates

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E3 Ligase Ligand-Linker Conjugates

E3 Ligase Ligand-Linker Conjugate, which is one part of Proteolysis Targeting Chimeric Molecules (PROTACs), incorporates a ligand for the E3 ubiquitin ligase and a linker.These conjugates can be used to create PROTACs that target proteins for ubiquitination and destruction after being coupled to the ligand for the target protein (for example, JQ1 for the BRD4 protein or Molibresib for the BET protein). Currently, a number of PROTACs that specifically target BET, the estrogen receptor (ER), the androgen receptor, etc. have been identified to demonstrate good biological activity.

E3 Ligase Ligand-Linker Conjugates related products

Cat No.	Product Name	CAS No.	Product Description
V82348	endo-BCN-PEG4-Val-Cit-PAB-MMAE	2762519-08-2	endo-BCN-PEG4-Val-Cit-PAB-MMAE is a cleavable ADC (Antibody-drug conjugate) linker containing 4 PEG (polyethylene glycol) units, which may be utilized to prepare active ADC molecules.
V82499	Fmoc-NH-PEG25-CH2CH2COOH	1257223-69-0	Fmoc-NH-PEG25-CH2CH2COOH is a PROTAC (PROteolysis TArgeting Chimera) linker of the PEG category, may be utilized to prepare PROTAC protein degraders.
V82417	Fmoc-PEG3-alcohol	560088-66-6	Fmoc-PEG3-alcohol is a PROTAC (PROteolysis TArgeting Chimera) linker, which belongs to the Polyethylene glycol (PEG) category and may be utilized to prepare PROTAC protein degraders.
V33147	Fmoc-Val-Cit-PAB-MMAE	1350456-56-2	Fmoc-Val-Cit-PAB-MMAE is a novel drug-linker conjugate used for ADC.
V82508	Folate-PEG1-mal	2743004-48-8	Folate-PEG1-mal is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders.
V82340	Glucose oxidase	9001-37-0	Glucose oxidase may be used in the food and beverage industry as a preservative and stabilizer and is usually derived from the fungus Aspergillus niger.
V82395	HG-7-85-01-Decyclopropane (PROTAC ABL binding moiety 3)	2444044-44-2	HG-7-85-01-Decyclopropane is a ligand based on HG-7-85-01 (ABL inhibitor), which can bind to IAP ligand through a linker to form a SNIPER molecule.
V82482	HO-PEG7-CH2COOH	2250056-27-8	HO-PEG7-CH2COOH is a PROTAC (PROteolysis TArgeting Chimera) linker of the PEG category, may be utilized to prepare PROTAC protein degraders.
V82441	HyNic-PEG2-DBCO	2741281-12-7	HyNic-PEG2-DBCO is a PROTAC (PROteolysis TArgeting Chimera) linker and belongs to the PEG category, may be utilized to prepare PROTAC molecules.
V82341	IMD-biphenylA	2928463-40-3	IMD-biphenylA is a novel imidazoquinolinone NF-κB Immune-modulatory dimer that can improve the adjuvant properties of small molecule immune enhancers.
V82358	IMD-vanillin	2928463-38-9	IMD-vanillin is a novel imidazoquinolinone NF-κB Immune-modulatory dimer.
V82359	IR-Crizotinib	2387927-74-2	IR-Crizotinib is an NF-κB inducing kinase (NIK) inhibitor that can cross the BBB (blood-brain barrier) and fluorescently localize glioblastoma (GBM) in the brain of mice (IC50= 3.381 μM).
V84864	Lenalidomide 4'-PEG1-azide	2399455-45-7
V82517	Lenalidomide-4-aminomethyl	790652-68-5	Lenalidomide-4-aminomethyl is a Lenalidomide-based E3 ubiquitin ligase cereblon (CRBN) ligand used to recruit cereblon proteins.
V82463	Lenalidomide-4-aminomethyl hydrochloride	444289-05-8	Lenalidomide-4-aminomethyl HCl is a Lenalidomide-based E3 ubiquitin ligase cereblon (CRBN) ligand used to recruit cereblon proteins.
V82354	LY2409881	946518-61-2	LY2409881 is a selective IκB kinase beta (IKK2) inhibitor (antagonist) with IC50 of 30 nM.
V82514	m-PEG19-alcohol	2412813-38-6	m-PEG19-alcohol is a PROTAC (PROteolysis TArgeting Chimera) linker, which belongs to the Polyethylene glycol (PEG) category and may be utilized to prepare PROTAC.
V82476	m-PEG3-phosphonic acid	96962-42-4	m-PEG3-phosphonic acid is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders.
V82505	m-PEG9-azide	1354521-95-1	m-PEG9-azide is a PROTAC (PROteolysis TArgeting Chimera) linker and belongs to the PEG (Polyethylene glycol) class.
V82366	Mal-amido-PEG24-TFP ester	2384191-62-0	Mal-amido-PEG24-TFP ester is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders.