E3 Ligase Ligand-Linker Conjugate, which is one part of Proteolysis Targeting Chimeric Molecules (PROTACs), incorporates a ligand for the E3 ubiquitin ligase and a linker.These conjugates can be used to create PROTACs that target proteins for ubiquitination and destruction after being coupled to the ligand for the target protein (for example, JQ1 for the BRD4 protein or Molibresib for the BET protein). Currently, a number of PROTACs that specifically target BET, the estrogen receptor (ER), the androgen receptor, etc. have been identified to demonstrate good biological activity.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
|
V82429 | Methyl acetate-PEG1-methyl acetate | 54665-51-9 | Methyl acetate-PEG1-methyl acetate is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders. |
|
V82452 | Methyl-PEG3-Ald | 141981-62-6 | Methyl-PEG3-Ald is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders. |
|
V82465 | Methylamino-PEG3-t-butyl ester | 217817-03-3 | Methylamino-PEG3-t-butyl ester is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders. |
|
V82375 | Ms-PEG6-Ms | 109789-40-4 | Ms-PEG6-Ms is a PROTAC (PROteolysis TArgeting Chimera) linker of the PEG category, may be utilized to prepare PROTAC protein degraders. |
|
V82428 | Ms-PEG6-THP | 42607-89-6 | Ms-PEG6-THP is a PROTAC (PROteolysis TArgeting Chimera) linker of the PEG category, may be utilized to prepare PROTAC protein degraders. |
|
V82405 | N-(m-PEG4)-N'-(PEG4-acid)-Cy5 | 2107273-32-3 | N-(m-PEG4)-N'-(PEG4-acid)-Cy5 is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders. |
|
V82472 | N-Boc-PEG10-alcohol | 2238844-74-9 | N-Boc-PEG10-alcohol is a PROTAC (PROteolysis TArgeting Chimera) linker of the PEG category. |
|
V80903 | N-Boc-SBP-0636457-O-C3-COOH | N-Boc-SBP-0636457-OH is a synthetic E3 ligase ligand conjugate that contains IAP ligand and linker. | |
|
V82409 | N-Ethylpropionamide-PEG1-Br | 1539080-27-7 | N-Ethylpropionamide-PEG1-Br is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders. |
|
V82342 | Narlumosbart | 2646587-68-8 | Narlumosbart (JMT103) is an IgG4κ antibody targeting receptor agonist/activator of nuclear factor-κB ligand (RANKL). |
|
V82373 | NH2-PEG3 hydrochloride | 92505-84-5 | NH2-PEG3 HCl is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders. |
|
V82507 | NH2-PEG5-C1-Boc | 2231845-67-1 | NH2-PEG5-C1-Boc is a PROTAC (PROteolysis TArgeting Chimera) linker of the PEG category, may be utilized to prepare PROTAC protein degraders. |
|
V76688 | Nutlin-C1-amido-PEG4-C2-N3 (MDM2 Ligand-Linker Conjugates 1; E3 ligase Ligand-Linker Conjugates 48) | Nutlin-C1-amido-PEG4-C2-N3 is a synthetic E3 ligase (e.g. CRBN) ligand-linker conjugate containing a Nutlin 3-based MDM2 ligand and a 4-unit PEG linker. | |
|
V82473 | PCDBCO-PEG4-NHS ester | 2055025-02-8 | PC DBCO-PEG4-NHS ester is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders. |
|
V82370 | PEG2-Cl | 78925-46-9 | PEG2-Cl is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders. |
|
V82498 | PEG2-ethyl acetate | 154773-33-8 | PEG2-ethyl acetate is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders. |
|
V82493 | Phthalimide-PEG3-C2-OTs | 382162-12-1 | Phthalimide-PEG3-C2-OTs (Compound 5) is a PROTAC (PROteolysis TArgeting Chimera) linker and belongs to the PEG (Polyethylene glycol) class. |
|
V51728 | Pom-8PEG | 2488761-03-9 | Pom-8PEG, a ligand (for E3 ligase)-linker conjugate, contains a cereblon (CRBN) ligand for E3 ubiquitin ligase and an 8-unit PEG linker. |
|
V84833 | Pomalidomide 4'-alkylC2-azide | 2296708-61-5 | |
|
V84678 | Pomalidomide 4'-alkylC3-acid | 2225940-47-4 |
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