FGFR (Fibroblast growth factor receptors) are the receptors that bind to members of the fibroblast growth factor family of proteins.Pathological conditions involve some of these receptors. Achondroplasia can be brought on by a point mutation in FGFR3. Vertebrates have been found to contain five distinct membrane FGFRs, all of which are members of the tyrosine kinase superfamily (FGFR1, FGFR2, FGFR3, FGFR4, FGFR6). One of the most significant families of paracrine factors that function in the development process is the fibroblast growth factor family. They control which cells differentiate into mesoderm, the production of blood vessels, the growth of limbs, and the growth and differentiation of many different cell types.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V3276 | ACTB-1003 | 939805-30-8 | ACTB-1003 is an orally available multi-kinase inhibitorwithIC50values of 6, 2 and 4 nM forFGFR1,VEGFR2andTie-2. |
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V88041 | Antitumor agent-176 | Antitumor agent-176 (Compound 22) is an antitumor agent that potently binds to FGF2 and inhibits fibroblast growth factor receptor (FGFR) activation in multiple myeloma (MM) cells, with significant in vivo effects on MM and in vitro antitumor activity. | |
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V88043 | Antitumor agent-177 | Antitumor agent-177 (compound 57) is a nonsteroidal NSC12 derivative that displays potent FGF2 binding affinity with a Kd of 24 μM as measured by SPR. | |
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V5222 | ASP-5878 | 1453208-66-6 | ASP5878 is a novel, potent,selective and orally bioactive inhibitor of FGFR 1, 2, 3, and 4, with IC50values of 0.47 nM, 0.6 nM, 0.74 nM and 3.5 nM for FGFR 1, 2, 3, and 4 kinase activity. |
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V98041 | AZ8010 | 1035270-44-0 | AZ8010 (AZ12908010) is a potent FGFR1-3 inhibitor. |
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V87107 | B-Raf IN 17 | B-Raf IN 17 (Compound 8e) is a potent and orally active type II multikinase inhibitor. | |
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V2693 | BLU-554(BLU-554) | 1707289-21-1 | BLU-554 is a novel potent, highly-selective, and orally bioavailable inhibitor of FGFR4 (fibroblast growth factor receptor 4) with an IC50 value of 5 nM in cell free assays. |
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V0617 | BLU9931 | 1538604-68-0 | BLU9931 (BLU-9931; BLU 9931) is an irreversible and selective FGFR4 inhibitor with potential anticancer activity. |
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V37655 | BO-264 | 2408648-20-2 | BO-264 is a novel and orally bioactive transforming acidic coiled-coil 3 (TACC3) inhibitor with an IC50 of 188 nM and a Kd of 1.5 nM. |
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V88031 | BR-cpd7 | BR-cpd7 is a PROTAC degrader of fibroblast growth factor receptor (FGFR1/2) with a DC50 of 10 nM. | |
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V86160 | CEP-11981 tosylate (ESK981 tosylate; BOL 303213X tosylate) | 901128-79-8 | |
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V69468 | CPL304110 | 1627826-19-0 | CPL304110 is a potent, orally bioavailable, and selective inhibitor of the fibroblast growth factor receptor FGFR (1-3) with IC50s of 0.75 nM, 0.5 nM, and 3.05 nM for FGFR (1-3). |
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V88040 | CXF-007 | 2727083-99-8 | CXF-007 is a potent and specific FGFR4 inhibitor with an IC50 value of 7 nM. |
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V88039 | CXF-009 | 2727084-00-4 | CXF-009 is a selective, covalent FGFR4 inhibitor with an IC50 value of 48 nM. |
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V84741 | CYY292 | 2644673-04-9 | |
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V69485 | Efruxifermin | 2375240-92-7 | Efruxifermin is an Fc-FGF21 fusion protein (human IgG1 Fc domain linked to modified human FGF21). |
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V93776 | Fanregratinib | 1628537-44-9 | Fanregratinib is a fibroblast growth factor receptor (FGFR) tyrosine kinase inhibitor. |
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V0616 | Fexagratinib (AZD-4547; ADSK-091) | 1035270-39-3 | AZD4547 (AZD-4547; AZD 4547) is a novel and orally bioavailable FGFR (fibroblast growth factor receptor) inhibitor with potential antineoplastic activity. |
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V69458 | FGFR-IN-1 | 1513860-41-7 | FGFR-IN-1 is a potent FGFR inhibitor (antagonist) with IC50 of less than 100 nM for FGFR1, FGFR2 and FGFR3 respectively. |
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V69466 | FGFR-IN-11 | 2658488-68-5 | FGFR-IN-11 (compound I-5) is an orally bioactive and covalent pan-FGFR inhibitor (antagonist) with IC50s of 9.9 nM (FGFR1), 3.1 nM (FGFR2), 16 nM (FGFR3) and 1.8 respectively. |
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