In the central nervous system (CNS) of vertebrates, dopamine receptors are a class of G protein-coupled receptors that are widely distributed. The main endogenous ligand for dopamine receptors is the neurotransmitter dopamine. Numerous neurological functions, including motivation, pleasure, cognition, memory, learning, and fine motor control, as well as the modulation of neuroendocrine signaling, are associated with dopamine receptors.Numerous neuropsychiatric disorders have abnormal dopamine receptor signaling and dopaminergic nerve function at their core. Dopamine receptors are therefore typical neurologic drug targets; psychostimulants are typically indirect agonists of dopamine receptors, whereas antipsychotics are frequently dopamine receptor antagonists. Dopamine receptors come in at least five different subtypes: D1, D2, D3, D4, and D5. The D2, D3, and D4 dopamine receptors are members of the D2-like family, whereas the D1 and D5 receptors belong to the D1-like family.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V4667 | SCH-23390 | 125941-87-9 | SCH 23390 hydrochloride is a novel and potentdopamine receptor antagonist withKivalues of 0.2 and 0.3 nM for the D1 and D5. |
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V2162 | SCH-23390 maleate | 87134-87-0 | SCH-23390 is a potent dopamine receptor antagonist (Ki values are 0.2 nM and 0.3 nM at D1 and D5 receptor sub-types, respectively). |
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V71714 | SKF 81297 | 71636-61-8 | SKF 81297 is a potent and specific dopamine D1 receptor agonist (activator). |
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V4977 | SKF 82958 | 74115-01-8 | SKF-82958 HBr, the hydrobromide salt of SKF-81297, is a novel, potent and selective dopamine D1/D5 receptor full agonist which stimulates motor behaviour of MPTP-lesioned monkeys. |
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V71143 | SKF-83566 | 99295-33-7 | SKF-83566 is a potent, BBB (blood-brain barrier) permeable (penetrable), orally bioactive D1-like dopamine receptor antagonist. |
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V71149 | SKF-83566 hydrobromide | 108179-91-5 | SKF-83566 HBr is a potent, BBB (blood-brain barrier) permeable (penetrable), orally bioactive D1-like dopamine receptor antagonist, which can also work as a weaker competitive antagonist. |
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V1251 | SKF38393 HCl | 62717-42-4 | SKF 38393 HCl (SKF38393; SKF-38,393; SKF 38,393; SKF-38393A), the hydrochloride salt of SKF-38393, is a novel potent and selective dopamine D1 receptor agonist with IC50 of 110 nM, and the (+)-enantiomer is the active isomer. |
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V71775 | SKF83822 hydrobromide | 74115-10-9 | SKF83822 HBr is a dopamine D1 receptor agonist. |
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V71780 | Sonepiprazole (PNU-101387G; U-101387G) | 170858-33-0 | Sonepiprazole (PNU-101387G) is a selective D4 dopamine antagonist (inhibitor) with Ki of 3.6, 10.1, 5147 and 7430 nM for rD4 dopamine, hD4.2 dopamine, rD2 dopamine and histamine H1 receptors, respectively. |
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V15137 | Spiperone | 749-02-0 | Spiperone (E-525; R-5147; Spiroperidol) is a novel and potent antipsychotic agent acting as adopamine D2, serotonin 5-HT1A, and serotonin 5-HT2A antagonist with the potential for neurology diseases. |
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V15138 | Spiperone HCl | 2022-29-9 | Spiperone HCl (NSC-170983; E-525; R-5147; Spiroperidol) is a novel and potent antipsychotic agent acting as a dopamine D2, serotonin 5-HT1A, and serotonin 5-HT2A antagonist with the potential for neurology diseases. |
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V85479 | Sumanirole (PNU-95666E) | 179386-43-7 | |
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V15535 | Sumanirole maleate | 179386-44-8 | Sumanirole maleate (U-95666E; PNU-95666), the maleate salt of Sumanirole, is a first-in-class and highly selective D2 receptor full agonist (ED50 = ~46 nM) with antiparkinsonian effects. |
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V15792 | Tavapadon (PF6649751; CVL751) | 1643489-24-0 | Tavapadon (PF-6649751; CVL-751) is a partial dopamine receptor agonist with the potential to be used in the treatment of Parkinsons disease and Alzheimers. |
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V1247 | Tetracaine HCl | 136-47-0 | Tetracaine HCl (also called Amethocalne; Butylocaine; Curtacain; Decicain; Gingicain; PantocaineM; Intercaine; Leocaine; Menonasal; Niphanoid), thehydrochloride salt form of tetracaine, is a local anaesthetic and a channel function allosteric inhibitor. |
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V30298 | Tetrahydroberberine | 522-97-4 | Tetrahydroberberine is a natural isoquinoline alkaloid extractedfrom corydalis tuber with micromolar affinity for dopamine D(2) (pK(i) = 6.08) and 5-HT(1A) (pK(i) = 5.38) receptors but moderate to no affinity for other relevant serotonin receptors (5-HT(1B), 5-HT(1D), 5-HT(3), and 5-HT(4); pK(i) < 5.00). |
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V60107 | Tetrahydropalmatine hydrochloride | 6024-85-7 | Tetrahydropalmatine (also known as DL-Tetrahydropalmatine) hydrochloride has analgesic properties. Tetrahydropalmatine hydrochloride prevents a rat epileptic seizure by blocking the release of dopamine from amygdaloid. |
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V71735 | Trazpiroben (TAK-906) | 1352993-39-5 | Trazpiroben (Taku-906) is a dopamine D2/D3 receptor blocker (antagonist) indicated for the study of chronic moderate to severe gastroparesis. |
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V71781 | Trimethobenzamide (Ro 2-9578 free base) | 138-56-7 | Trimethobenzamide (Ro 2-9578 free base) is a dopamine D2 receptor antagonist (blocker) that is used as an antiemetic to prevent nausea and vomiting. |
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V2067 | Trimethobenzamide HCl (Ro 2-9578) | 554-92-7 | rimethobenzamide (also known as Ro 2-9578; trade names Tebamide, Tigan), a blocker of the D2 receptor, is a potent antiemetic that is used to prevent nausea and vomiting. |
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