The neurotransmitter glutamate activates the iGluR (ionotropic glutamate receptor), an ion channel that is ligand-gated. The central ion channel pore is formed by four large subunits of the integral membrane protein iGluR. All known glutamate receptor subunits, including the AMPA, kainate, NMDA, and receptors, share a similar amino acid sequence.
The primary charge carriers during basal transmission are AMPA receptors, which allow an influx of sodium ions to depolarize the postsynaptic membrane. Magnesium ions block NMDA receptors, which only allow ion flux after a previous depolarization. They can now serve as coincidence detectors for synaptic plasticity because of this. NMDA receptors allow calcium to enter the body, which permanently changes how strongly synaptic transmission is carried out.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V87171 | CGP-78608 | 206648-13-7 | CGP 78608 is a highly potent and selective antagonist of the glycine binding site of NMDA receptors with an IC50 of 6 nM. |
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V18373 | CIQ | 486427-17-2 | CIQ is a novel, potent and GluN2C/GluN2D subunit-selective NMDA receptor potentiator, which reverses MK-801-induced impairment in prepulse inhibition and working memory in Y-maze test in mice. |
|
V70468 | cis-ACPD | 477331-06-9 | cis-ACPD is a potent NMDA receptor agonist/activator with IC50 of 3.3 μM. |
|
V70467 | Cl-HIBO | 909400-43-7 | Cl-HIBO is a highly isoform-selective GluR1/2 agonist (EC50 of 4.7 and 1.7 μM, respectively). |
|
V18479 | CNQX Disodium | 479347-85-8 | CNQX Disodium (FG-9065), the disodium salt form of CNQX, is a potent AMPA/kainate antagonist with higherwater-solubility than the free acid formCNQX(Cat. |
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V93661 | Co 101244 | 193359-26-1 | Co-101244 (PD 174494) is an NMDA receptor blocker that specifically targets the NR2B subunit. |
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V78852 | Conantokin G TFA | Conantokin G TFA is a 17 amino acid (AA) peptide that is a specific and competitive N-methyl-D-aspartate (NMDA) receptor antagonist. | |
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V70477 | Conantokin R (Con-R) | 202925-60-8 | Conantokin R (Con-R) is an NMDA receptor peptide antagonist (inhibitor) with IC50 of 93 nM. |
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V70484 | Conantokin-T | 127476-26-0 | Conantokin-T is an N-methyl-D-aspartate (NMDA) antagonist peptide containing γ-carboxyglutamate with IC50 of 2 μM. |
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V70449 | CP-465022 hydrochloride | 1785666-59-2 | CP-465022 HCl is a specific, noncompetitive AMPA receptor antagonist (inhibitor) with anticonvulsant (antiepileptic/antiseizure) activity. |
|
V77135 | Crocetin meglumine (Transcrocetin meglumine; trans-Crocetin meglumine) | Crocetin (Transcrocetin) meglumine, found in saffron (Crocus sativus L.), is a high-affinity NMDA receptor antagonist. | |
|
V18913 | CX546 | 215923-54-9 | CX546 is an AMPA receptor potentiator. |
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V70388 | Cycloleucine (Cycloleucine) | 52-52-8 | Cycloleucine is a specific inhibitor of S-adenosylmethionine-mediated methylation. |
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V70488 | D-AP4 (D-APB; D-2-Amino-4-phosphonobutyric acid) | 78739-01-2 | D-AP4 (D-APB; D-2-Amino-4-phosphonobutyric acid) is a phosphate analog of glutamate and an NMDA broad-spectrum excitatory amino acid (AA) receptor antagonist. |
|
V70434 | D-NMAPPD ((1R,2R)-B13) | 35922-06-6 | D-NMAPPD ((1R,2R)-B13) is an acid ceramidase inhibitor. |
|
V70448 | Decanoic acid-d19 (decanoic acid d19) | 88170-22-3 | Decanoic acid-d199 is the deuterated form of Decanoic acid. |
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V70490 | Decanoic acid-d2 (decanoic acid d2) | 62716-49-8 | Decanoic acid-d2 is the deuterated form of Decanoic acid. |
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V70422 | Decanoic acid-d3 (decanoic acid d3) | 102611-15-4 | Decanoic acid-d3 is the deuterated form of Decanoic acid. |
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V87170 | Delucemine | 186495-49-8 | Delucemine is a selective serotonin reuptake inhibitor (SSRI) and NMDAR antagonist. |
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V102444 | DL-AP5 lithium | 125229-62-1 | DL-AP5 (2-APV) lithium is a competitive NMDA (N-methyl-D-aspartate) receptor antagonist. |
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