Cell membrane blebbing, chromatin condensation, genomic DNA fragmentation, and the exposure of particular phagocytosis signaling molecules on the cell surface are just a few of the distinctive morphological and biochemical features of the cell death process known as apoptosis. Apoptosis-initiated cell death is distinct from necrosis-induced cell death. Apoptotic death, in contrast, is silent and orderly. Necrotic cells are typically recognized as a danger signal by the immune system, which causes inflammation.
There are two main methods for inducing apoptotic cell death: The intrinsic pathway, also known as the Bcl-2-regulated or mitochondrial pathway, is strictly regulated by the BCL-2 family of proteins and is activated by a variety of developmental cues or cytotoxic insults, such as viral infection, DNA damage, and growth-factor deprivation.The tumor necrosis factor (TNF) receptor family members, such as Fas or TNF receptor-1 (TNFR1), which contain an intracellular death domain and can recruit and activate caspase-8 through the adaptor protein Fas-associated death domain (FADD; also known as MORT1) at the cell surface, are what initiate the extrinsic or death-receptor pathway. Without the involvement of the BCL-2 family, this recruitment results in the subsequent activation of downstream (effector) caspases like caspase-3, -6, or -7.
Numerous human diseases, including cancer, viral infections, autoimmune diseases, neurodegenerative disorders, and AIDS (acquired immunodeficiency syndrome), may be influenced by changes in cell survival, according to studies. Some of these diseases may not progress naturally unless specific therapies that change the apoptotic threshold are used.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V43943 | MG-277 | 2411085-89-5 | MG-277 is a molecular glue degrader that can effectively induce the degradation of the translation termination factor GSPT1 based on Cereblon E3 ligand, with DC50 of 1.3 nM. |
|
V48932 | MGH-CP1 | 896657-58-2 | MGH-CP1 is a potent and orally bioactive inhibitor of TEAD2 and TEAD4 autopalmitoylation with IC50s of 710 nM and 672 nM, respectively. |
|
V41523 | MI-1061 TFA | 1410737-35-7 | MI-1061 TFA is a potent, orally bioavailable, chemically stable MDM2 (MDM2-p53 interaction) inhibitor (IC50=4.4 nM; Ki=0.16 nM). |
|
V54880 | Microcystin-RR (Cyanoviridin RR) | 111755-37-4 | Microcystin-RR (Cyanoviridin RR) is a potent orally bioactive protein phosphatase inhibitor. |
|
V84262 | Microtubule inhibitor 9 | ||
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V41194 | Millepachine | 1393922-01-4 | Millepachine is a bioactive natural chalcone derived from the Chinese herbal medicine Millettia pachycarpa Benth, which shows potent anti-tumor effects on a variety of human cancer cells in vitro and in vivo. |
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V53161 | Minodronic acid (YM-529) | 180064-38-4 | Minodronic acid (YM-529) is a third-generation bisphosphate that directly or indirectly prevents proliferation, causes apoptosis, and inhibits the metastasis of various types of cancer cells. |
|
V41191 | Mitazalimab (ADC-1013; JNJ-64457107) | 2055640-86-1 | Mitazalimab (ADC-1013; JNJ-64457107) is an FcγR-dependent CD40 agonist/activator with tumor-targeting activity. |
|
V13504 | MitoBloCK-6 | 303215-67-0 | MitoBloCK-6 is a potent Erv1/ALR inhibitor (antagonist) with IC50 of 900 nM and 700 nM respectively. |
|
V11169 | MitoEbselen-2 | 1638973-78-0 | MitoEbselen-2 (MitoPeroxidase-2), anEbselen derivative,is a novel and potent radiation mitigator. |
|
V56428 | Mitotane-13C6 (mitotane-13d6; 2,4′-DDD-13C6; o,p'-DDD-13C6) | 1261396-21-7 | Mitotane-13C6 is 13C (carbon 13)-labeled Mitotane. |
|
V52694 | Mitotane-d8 (mitotane-d8; 2,4′-DDD-d8; o,p'-DDD-d8) | 2673270-14-7 | Mitotane-d8 is the deuterium labelled form of Mitotane. |
|
V41188 | MK-886 sodium salt (L 663536 sodium salt) | 118427-55-7 | MK-886 (L 663536) sodium salt is a potent, cell-permeable (penetrable) and orally bioactive FLAP (IC50 of 30 nM) and leukotriene biosynthesis (IC50 of 3 in intact leukocytes and human whole blood, respectively) nM and 1.1μM) inhibitors. |
|
V41187 | ML311 | 315698-17-0 | ML311 is a potent and specific inhibitor of the Mcl-1/Bim protein interaction. |
|
V41183 | MM-401 TFA | 1442106-11-7 | MM-401 (TFA) is an MLL1 H3K4 methyltransferase inhibitor. |
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V54835 | MMPSI | 220509-74-0 | MMPSI is a potent and specific small molecule inhibitor of caspase 3 and caspase 7, with IC50 of 1.7 μM for human caspase-3. |
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V56438 | Moexipril-d5 | 1356929-49-1 | Moexipril-d5 is the deuterium labelled form of Moexipril. |
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V30240 | Momordicoside G (Momordicacoside G) | 81371-54-2 | Momordicoside G (Momordicacoside G) is an orally bioavailable cucurbitane-type triterpene glycoside. |
|
V84955 | Monaspin B | 2897653-87-9 | |
|
V41177 | Moracin D | 69120-07-6 | Moracin D is a flavonoid that can be found in the mulberry tree. |
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