Cell membrane blebbing, chromatin condensation, genomic DNA fragmentation, and the exposure of particular phagocytosis signaling molecules on the cell surface are just a few of the distinctive morphological and biochemical features of the cell death process known as apoptosis. Apoptosis-initiated cell death is distinct from necrosis-induced cell death. Apoptotic death, in contrast, is silent and orderly. Necrotic cells are typically recognized as a danger signal by the immune system, which causes inflammation.
There are two main methods for inducing apoptotic cell death: The intrinsic pathway, also known as the Bcl-2-regulated or mitochondrial pathway, is strictly regulated by the BCL-2 family of proteins and is activated by a variety of developmental cues or cytotoxic insults, such as viral infection, DNA damage, and growth-factor deprivation.The tumor necrosis factor (TNF) receptor family members, such as Fas or TNF receptor-1 (TNFR1), which contain an intracellular death domain and can recruit and activate caspase-8 through the adaptor protein Fas-associated death domain (FADD; also known as MORT1) at the cell surface, are what initiate the extrinsic or death-receptor pathway. Without the involvement of the BCL-2 family, this recruitment results in the subsequent activation of downstream (effector) caspases like caspase-3, -6, or -7.
Numerous human diseases, including cancer, viral infections, autoimmune diseases, neurodegenerative disorders, and AIDS (acquired immunodeficiency syndrome), may be influenced by changes in cell survival, according to studies. Some of these diseases may not progress naturally unless specific therapies that change the apoptotic threshold are used.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
|
V53343 | Nitrochin (4-NQO) | 56-57-5 | Nitrochin (4-NQO) is a chemical carcinogen. |
|
V54815 | Nortrachelogenin ((-)-Wikstromol; (-)-Nortrachelogenin) | 34444-37-6 | Nortrachelogenin ((-)-Wikstromol) is extracted from Partrinia scabiosaefolia and can cause apoptosis in Candida albicans. |
|
V52551 | Nortriptyline-d3 hydrochloride (Desmethylamitriptyline-d3 (hydrochloride); Desitriptilina-d3 (hydrochloride)) | 203784-52-5 | Nortriptyline-d3 ( HCl) is the deuterated form of Nortriptyline HCl. |
|
V4691 | NS 3694 | 426834-38-0 | NS3694 is a diaryl urea compound and an apoptosome inhibitor. |
|
V53074 | NSC 107512 | 22242-89-3 | NSC 107512 is a potent cyclin-dependent kinase 9 (CDK9) inhibitor. |
|
V54876 | NSC 48160 | 6640-90-0 | NSC 48160 suppresses the growth of pancreatic cancer cells with IC50 of 84.3 μM for CPFAC-1 and IC50 of 94.5 μM for BxPC-3. |
|
V86230 | NSC 689534 | 907958-80-9 | |
|
V5102 | NSC-144303 | 108477-18-5 | NSC 144303 (also known as Ubiquitin Isopeptidase Inhibitor I, G5) is a novel and potent apoptosome-independentcaspaseandapoptosisactivator withIC50values of 1.76 and 1.6 μM in E1A and E1A/C9DN cells, respectively. |
|
V54260 | NSC260594 | 906718-66-9 | NSC260594 causes apoptosis. |
|
V5039 | NSC348884 | 81624-55-7 | NSC348884 is a novel and potent nucleophosmin inhibitor that is able to disrupt oligomer formation and induces apoptosis, it inhibits cell proliferation at an IC50 of 1.7-4.0 μM in distinct cancer cell lines. |
|
V84750 | NT-B2R | ||
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V54847 | NTR 368 | 197230-90-3 | NTR 368 is a bioactive peptide extracted from the p75 neurotrophin receptor (p75NTR) and corresponds to residues 368-381 of the human receptor. |
|
V80975 | NTR 368 TFA | NTR 368 TFA is a bioactive peptide extracted from the p75 neurotrophin receptor (p75NTR), corresponding to residues 368-381 of the human receptor. | |
|
V41086 | Nur77 modulator 1 | 2469975-55-9 | Nur77 modulator 1 binds to Nur77 (KD = 3.58 μM). |
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V54919 | NWP-0476 | 2290611-26-4 | NWP-0476 is a BCL-2/BCL-xL inhibitor. |
|
V41083 | NY2267 | 886053-73-2 | NY2267 is a Myc-Max interaction interferent with IC50 of 36.5 μM. |
|
V41074 | OBAA | 134531-42-3 | OBAA is a potent inhibitor of phospholipase A2 (PLA2) with IC50 of 70 nM. |
|
V54984 | Oditrasertib | 2252271-93-3 | Oditrasertib is a RIPKl inhibitor (antagonist) with IC50 of less than 100 nM. |
|
V53368 | Odoroside A | 12738-19-1 | Odoroside A is an active ingredient found in oleander leaves. |
|
V25184 | Oenothein B | 104987-36-2 | Oenothein B is a dimeric macrocyclic ellagitannin with broad bioactivities such as antioxidant, anti-inflammatory, antifungal, anti-HCV (hepatitis C virus), and anti-tumor properties. |
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