Cell membrane blebbing, chromatin condensation, genomic DNA fragmentation, and the exposure of particular phagocytosis signaling molecules on the cell surface are just a few of the distinctive morphological and biochemical features of the cell death process known as apoptosis. Apoptosis-initiated cell death is distinct from necrosis-induced cell death. Apoptotic death, in contrast, is silent and orderly. Necrotic cells are typically recognized as a danger signal by the immune system, which causes inflammation.
There are two main methods for inducing apoptotic cell death: The intrinsic pathway, also known as the Bcl-2-regulated or mitochondrial pathway, is strictly regulated by the BCL-2 family of proteins and is activated by a variety of developmental cues or cytotoxic insults, such as viral infection, DNA damage, and growth-factor deprivation.The tumor necrosis factor (TNF) receptor family members, such as Fas or TNF receptor-1 (TNFR1), which contain an intracellular death domain and can recruit and activate caspase-8 through the adaptor protein Fas-associated death domain (FADD; also known as MORT1) at the cell surface, are what initiate the extrinsic or death-receptor pathway. Without the involvement of the BCL-2 family, this recruitment results in the subsequent activation of downstream (effector) caspases like caspase-3, -6, or -7.
Numerous human diseases, including cancer, viral infections, autoimmune diseases, neurodegenerative disorders, and AIDS (acquired immunodeficiency syndrome), may be influenced by changes in cell survival, according to studies. Some of these diseases may not progress naturally unless specific therapies that change the apoptotic threshold are used.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
|
V54934 | OICR12694 (JNJ-65234637) | 2360625-97-2 | OICR12694 (JNJ-65234637) is an orally bioactive B-cell lymphoma 6 (BCL6) inhibitor. |
|
V54937 | OICR12694 TFA (JNJ-65234637 TFA) | 2360625-98-3 | OICR12694 (JNJ-65234637) TFA is an orally bioactive B-cell lymphoma 6 (BCL6) inhibitor. |
|
V35037 | Okadaic acid sodium | 209266-80-8 | Okadaic acid sodium is a marine toxin and an inhibitor (blocker/antagonist) of protein phosphatases (PP)such as PP1 (IC50=15-50 nM), PP2A (IC50=0.1-0.3 nM), PP3 (IC50=3.7-4 nM) , PP4 (IC50=0.1 nM) and PP5 (IC50=3.5 nM), which has the most significant affinity for PP2A but does not inhibit PP2C. |
|
V52814 | Oleic acid-13C (9-cis-Octadecenoic acid-13C; 9Z-Octadecenoic acid-13C) | 82005-44-5 | Oleic acid-13C is 13C (carbon 13) labelled Oleic acid. |
|
V56420 | Oleic acid-13C-1 (oleic acid 13C-1) | 2483735-58-4 | Oleic acid-13C-1 is 13C (carbon 13) labelled Oleic acid. |
|
V52540 | Oleic acid-13C18 (9-cis-Octadecenoic acid-13C18; 9Z-Octadecenoic acid-13C18) | 287100-82-7 | Oleic acid-13C18 is 13C (carbon 13) labelled Oleic acid. |
|
V56396 | Oleic acid-d17 (9-cis-Octadecenoic acid-d17; 9Z-Octadecenoic acid-d17) | 223487-44-3 | Oleic acid-d17 is the deuterated form of Oleic acid. |
|
V52775 | Oleic acid-d2 (9-cis-Octadecenoic acid-d2; 9Z-Octadecenoic acid-d2) | 5711-29-5 | Oleic acid-d2) is the deuterated form of Oleic acid. |
|
V41063 | Ompenaclid (Guanidinopropionic acid; RGX-202; 3-Guanidinopropionic acid) | 353-09-3 | Ompenaclid (RGX-202) is an orally bioactive SLC6A8 transporter inhibitor. |
|
V41062 | Onfekafusp alfa (L19TNF) | 1957239-88-1 | Onfekafusp alfa (L19TNF) is a homotrimer formed from an engineered peptide of the L19 antibody fused to human TNF in scFv form. |
|
V41061 | ONX 0801 trisodium (BGC 945 trisodium; Idetrexed trisodium; CB 300945 trisodium) | 1097638-00-0 | ONX 0801 (BGC 945) trisodium is an inhibitor (blocker/antagonist) of thymus kinase synthase (TS) that targets tumors overexpressing alpha folate receptors. |
|
V85027 | Ophiopogonin A | 11054-24-3 | |
|
V55001 | Opinercept | 2055118-96-0 | Opinercept is an inhibitor (blocker/antagonist) of tumor necrosis factor-alpha (TNF-alpha). |
|
V33775 | Oroxin B | 114482-86-9 | Oroxin B (OB) is a natural flavonoid extracted from the traditional Chinese herbal medicine Oroxylum indicum (Linn.) Bentham ex Kurz. |
|
V80184 | Osthole-d3 (osthole-d3; Osthol-d3; NSC 31868-d3) | Osthole-d3 is deuterated Osthole. | |
|
V41059 | OTS193320 | 2093401-33-1 | OTS193320 is an imidazo[1,2-a]pyridine compound and an inhibitor (blocker/antagonist) of SUV39H2 methyltransferase activity. |
|
V53115 | Oxazolone | 15646-46-5 | Oxazolone is a haptenizing agent that induces acute or chronic large intestinal inflammation and is used to model colitis. |
|
V56384 | Oxcarbazepine-d4 (GP 47680-d4) | 1020719-71-4 | Oxcarbazepine-d4 is the deuterium labelled form of Oxcarbazepine. |
|
V52547 | Oxybenzone-d5 (oxybenzone-d5; oxybenzone-d5; ultraviolet absorber UV-9-d5; benzophenone-3-d5) | 1219798-54-5 | Oxybenzone-d5 is the deuterium labelled form of Oxybenzone. |
|
V34517 | Oxychlororaphine | 550-89-0 | Oxychloroaphine can be extracted from Panthesia agglomerans, which occurs naturally in soil. |
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