Cell membrane blebbing, chromatin condensation, genomic DNA fragmentation, and the exposure of particular phagocytosis signaling molecules on the cell surface are just a few of the distinctive morphological and biochemical features of the cell death process known as apoptosis. Apoptosis-initiated cell death is distinct from necrosis-induced cell death. Apoptotic death, in contrast, is silent and orderly. Necrotic cells are typically recognized as a danger signal by the immune system, which causes inflammation.
There are two main methods for inducing apoptotic cell death: The intrinsic pathway, also known as the Bcl-2-regulated or mitochondrial pathway, is strictly regulated by the BCL-2 family of proteins and is activated by a variety of developmental cues or cytotoxic insults, such as viral infection, DNA damage, and growth-factor deprivation.The tumor necrosis factor (TNF) receptor family members, such as Fas or TNF receptor-1 (TNFR1), which contain an intracellular death domain and can recruit and activate caspase-8 through the adaptor protein Fas-associated death domain (FADD; also known as MORT1) at the cell surface, are what initiate the extrinsic or death-receptor pathway. Without the involvement of the BCL-2 family, this recruitment results in the subsequent activation of downstream (effector) caspases like caspase-3, -6, or -7.
Numerous human diseases, including cancer, viral infections, autoimmune diseases, neurodegenerative disorders, and AIDS (acquired immunodeficiency syndrome), may be influenced by changes in cell survival, according to studies. Some of these diseases may not progress naturally unless specific therapies that change the apoptotic threshold are used.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
|
V34468 | Oxypeucedanin | 737-52-0 | Oxypeucedanin is a furanocoumarin analogue extracted from Angelica dahurica. |
|
V86072 | Oxythiamine chloride (Hydroxythiamine chloride) | 582-36-5 | |
|
V34787 | Oxythiamine chloride hydrochloride (Hydroxythiamine chloride hydrochloride) | 614-05-1 | Oxythiamine (Hydroxythiamine) chloride HCl is an antimetabolite analogue that can inhibit the non-oxidative synthesis of ribose and causes apoptosis. |
|
V41055 | Ozoralizumab (ATN-103) | 1167985-17-2 | Ozoralizumab (ATN-103) is an anti-TNFα humanized antibody. |
|
V54972 | p53 Activator 3 | 2636839-90-0 | p53 Activator 3 (compound 87A) is a potent p53 activator with SC150 value <0.05 mM. |
|
V54973 | p53 Activator 5 | 2636840-37-2 | p53 Activator 5 (compound 134A) is a potent p53 activator with SC150 value <0.05 mM. |
|
V41052 | p53 Activator 7 | 2849340-59-4 | p53 Activator 7 is an activator of p53 mutant Y220C (MDM-2/p53) with EC50 of 104 nM. |
|
V53024 | p53 and MDM2 proteins-interaction-inhibitor dihydrochloride | 2070009-27-5 | p53 and MDM2 proteins-interaction-inhibitor diHCl is an inhibitor (blocker/antagonist) of the interaction between p53 and MDM2. |
|
V54976 | p53 CBS (p53 Consensus binding sequence) | 721963-21-9 | p53 CBS (p53 Consensus binding sequence) is a biologically active peptide. |
|
V54980 | p53-MDM2-IN-1 | 381717-91-5 | p53-MDM2-IN-1 (Example 30) is an inhibitor (blocker/antagonist) of p53-MDM2/X protein interaction with a Ki of 23.35 µM. |
|
V41053 | P53R3 | 922150-12-7 | P53R3 is a potent p53 reactivator that restores sequence-specific DNA binding of p53 hotspot mutants such as p53R175H, p53R248W, and p53R273H. |
|
V34757 | Paeoniflorigenone (paeoniflorigenone) | 80454-42-8 | Paeoniflorigenone is an active ingredient found in tree bark and has selective induction of apoptosis and anti-proliferation in tumor cells. |
|
V54887 | Pancratistatin ((+)-Pancratistatin) | 96203-70-2 | Pancratistatin is an isoquinoline alkaloid that can be extracted from the spider orchid Hymenocallis littoralis. |
|
V52685 | Panobinostat-d4 (LBH589-d4; NVP-LBH589-d4) | 1185237-51-7 | Panobinostat-d4 is the deuterium labelled form of Panobinostat. |
|
V41048 | PAO-Nap | 1613402-20-2 | PAO-Nap is PAO modified with NAP (naphthalimide) fluorophore. |
|
V41045 | PARP-1-IN-3 | 2976342-33-1 | PARP-1-IN-3 is a benzamide analogue and a potent PARP-1 inhibitor (antagonist) with IC50s of 0.25 nM and 2.34 nM for PARP-1 and PARP-2, respectively. |
|
V41041 | PARP-2-IN-3 | 2915650-86-9 | PARP-2-IN-3 (Compound 12) is a potent PARP-2 inhibitor (antagonist) with IC50 of 0.07 μM. |
|
V41047 | PARP1-IN-14 | 2098639-70-2 | PARP1-IN-14 (compound 19k) is a potent inhibitor of PARP1 with IC50 of 0.6 ± 0.1 nM. |
|
V41039 | Patritumab (Human Anti-ERBB3 Recombinant Antibody) | 1262787-83-6 | Patritumab (Human Anti-ERBB3 Recombinant Antibody) is a neutralizing monoclonal antibody (mAb) directed against ERBB3. |
|
V85364 | Patuletin | 519-96-0 |
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