Cell membrane blebbing, chromatin condensation, genomic DNA fragmentation, and the exposure of particular phagocytosis signaling molecules on the cell surface are just a few of the distinctive morphological and biochemical features of the cell death process known as apoptosis. Apoptosis-initiated cell death is distinct from necrosis-induced cell death. Apoptotic death, in contrast, is silent and orderly. Necrotic cells are typically recognized as a danger signal by the immune system, which causes inflammation.
There are two main methods for inducing apoptotic cell death: The intrinsic pathway, also known as the Bcl-2-regulated or mitochondrial pathway, is strictly regulated by the BCL-2 family of proteins and is activated by a variety of developmental cues or cytotoxic insults, such as viral infection, DNA damage, and growth-factor deprivation.The tumor necrosis factor (TNF) receptor family members, such as Fas or TNF receptor-1 (TNFR1), which contain an intracellular death domain and can recruit and activate caspase-8 through the adaptor protein Fas-associated death domain (FADD; also known as MORT1) at the cell surface, are what initiate the extrinsic or death-receptor pathway. Without the involvement of the BCL-2 family, this recruitment results in the subsequent activation of downstream (effector) caspases like caspase-3, -6, or -7.
Numerous human diseases, including cancer, viral infections, autoimmune diseases, neurodegenerative disorders, and AIDS (acquired immunodeficiency syndrome), may be influenced by changes in cell survival, according to studies. Some of these diseases may not progress naturally unless specific therapies that change the apoptotic threshold are used.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
|
V2002 | Bilobalide | 33570-04-6 | Bilobalide (BB)is a naturally occuring and biologically active terpenic trilactoneisolated from Ginkgo biloba (GB). |
|
V7932 | Astragalin | 480-10-4 | Astragalin is a novel and potent flavonoid. |
|
V21764 | Gracillin | 19083-00-2 | Gracillin is a steroidal saponin found in the roots of the plant that has anti-tumor properties. |
|
V19104 | Medicarpin | 32383-76-9 | Medicarpin isa naturally occuring flavonoidextracted from the herb of Hedysarum polybotrys Hand. |
|
V1875 | Evofosfamide (TH-302) | 918633-87-1 | Evofosfamide (TH-302) is potent and selective hypoxia-activated prodrug targeting hypoxic regions of solid tumors with IC50 of 19 nM, demonstrates 270-fold enhanced cytotoxicity under hypoxia versus their potency under aerobic conditions, stable to cytochrome P450 metabolism. |
|
V3417 | Brassinolide | 72962-43-7 | Brassinolide, a plant growth modulator and a plant hormone, is a sterol compound first isolated from pollen of rape (Brassica napus L.). |
|
V30122 | 5,7,4'-Trimethoxyflavone | 5631-70-9 | 5,7,4-Trimethoxyflavone is a naturally occuring flavnoid extracted from Kaempferia parviflora (KP) that is a famous medicinal plant from Thailand. |
|
V4717 | Aloperine | 56293-29-9 | Aloperine is an alkaloid found in the roots ofS. |
|
V2052 | Grape Seed Extract | 84929-27-1 | Grape Seed Extract is a natural product isolated from whole grape seeds that have a great concentration of vitamin E, flavonoids, linoleic acid, and OPCs. |
|
V30491 | Bufotalin | 471-95-4 | Bufotalin is a steroid lactone extracted from Venenum Bufonis with potent anti-tumor effects. |
|
V8390 | Mycophenolic acid (Mycophenolate) | 24280-93-1 | Mycophenolic acid (Mycophenolate) is an approved immunosuppressant drug used for preventing rejection in organ transplantation. |
|
V8035 | Aromadendrin (Dihydrokaempferol) | 480-20-6 | Aromadedrin, isolated fromBauhinia championii(Benth),also known asDihydrokaempferol, is a novel and potent inhibitor of protein kinase C. |
|
V60137 | Didymin | 14259-47-3 | Didymin is a dietary flavonoidglycoside from citrus fruits. it possesses antioxidant properties and induces apoptosis by inhibiting N-Myc and upregulating RKIP in neuroblastoma. |
|
V17150 | Bruceine D | 21499-66-1 | Bruceine D is a Notch inhibitor (antagonist) with anti-cancer effect and causes apoptosis in several human cancer/tumor cells. |
Products are for research use only; We do not sell to patients
Copyright 2020 InvivoChem LLC | All Rights Reserved
