Cell membrane blebbing, chromatin condensation, genomic DNA fragmentation, and the exposure of particular phagocytosis signaling molecules on the cell surface are just a few of the distinctive morphological and biochemical features of the cell death process known as apoptosis. Apoptosis-initiated cell death is distinct from necrosis-induced cell death. Apoptotic death, in contrast, is silent and orderly. Necrotic cells are typically recognized as a danger signal by the immune system, which causes inflammation.
There are two main methods for inducing apoptotic cell death: The intrinsic pathway, also known as the Bcl-2-regulated or mitochondrial pathway, is strictly regulated by the BCL-2 family of proteins and is activated by a variety of developmental cues or cytotoxic insults, such as viral infection, DNA damage, and growth-factor deprivation.The tumor necrosis factor (TNF) receptor family members, such as Fas or TNF receptor-1 (TNFR1), which contain an intracellular death domain and can recruit and activate caspase-8 through the adaptor protein Fas-associated death domain (FADD; also known as MORT1) at the cell surface, are what initiate the extrinsic or death-receptor pathway. Without the involvement of the BCL-2 family, this recruitment results in the subsequent activation of downstream (effector) caspases like caspase-3, -6, or -7.
Numerous human diseases, including cancer, viral infections, autoimmune diseases, neurodegenerative disorders, and AIDS (acquired immunodeficiency syndrome), may be influenced by changes in cell survival, according to studies. Some of these diseases may not progress naturally unless specific therapies that change the apoptotic threshold are used.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V77265 | AMXT-1501 tetrahydrochloride | AMXT-1501 tetra HCl is an orally bioactive polyamine transport inhibitor. | |
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V35054 | Amyloid 17-42 (Aβ(17-42)) | 155178-13-5 | Amyloid 17-42 (Aβ(17-42)) is the major component of precerebellar amyloid in diffuse plaques in AD/Alzheimer's disease and Down syndrome, consisting of the alpha and gamma amyloid precursor protein (APP). |
|
V30297 | Angelicin (Isopsoralen) | 523-50-2 | Angelicin is a naturally occurring tricyclic aromatic hydrocarbon compound that is structurally related to psoralen and has anti-cancer, anti~inflammatory, anti-viral and other activities. |
|
V34683 | Angiotensin II human acetate (Angiotensin II acetate; Ang II acetate; DRVYIHPF acetate) | 68521-88-0 | Angiotensin II human (Angiotensin II) acetate is a vasoconstrictor and the major biologically active peptide of the renin/angiotensin system. |
|
V34766 | Angiotensin II human TFA (Angiotensin II TFA; Ang II TFA; DRVYIHPF TFA) | 2761969-44-0 | Angiotensin II human (Angiotensin II) TFA is a vasoconstrictor and the major biologically active peptide of the renin/angiotensin system. |
|
V54825 | Angophorol | 133442-54-3 | Angophorol is a flavonoid compound. |
|
V56462 | Antcin A | 163597-24-8 | Antcin A is an NLRP3 inhibitor that can suppress the assembly and activation of the NLRP3 inflammasome. |
|
V52413 | Anti-CSCs agent-1 | 2251753-58-7 | Anti-CSCs agent-1 is an effective anti-CSCs agent. |
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V34832 | Anti-inflammatory agent 35 | 2293951-00-3 | Anti-inflammatory agent 35 (compound 5a27) is an orally bioavailable curcumin analog with anti-inflammatory activity. |
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V34831 | Anti-inflammatory agent 41 | 2896204-90-1 | Anti-inflammatory agent 41 (13a) significantly inhibited lipopolysaccharide (LPS)-induced expression of pro-inflammatory cytokines IL-6 and TNF-α in J774A. |
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V78935 | Anti-inflammatory agent 45 | Anti-inflammatory agent 45 (compound 2v) is an anticancer agent with direct inhibitory effects on the growth of different blood cancers such as leukemia, lymphoma and myeloma cell lines. | |
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V35026 | Anti-inflammatory agent 47 | 2925288-12-4 | Flo8 is a potent anti-inflammatory and antioxidant compound. |
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V55012 | Anti-inflammatory agent 54 | 2924156-46-5 | Anti-inflammatory agent 54 (compound 9c) is an analogue of Coixol and exhibits anti-inflammatory effect. |
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V55013 | Anti-inflammatory agent 55 | 2924156-51-2 | Anti-inflammatory agent 55 (compound 9j) is an analogue of Coixol and exhibits anti-inflammatory effect. |
|
V52410 | anti-TNBC agent-1 | 2289585-58-4 | anti-TNBC agent-1 is a potent anti-triple-negative breast cancer (TNBC) agent. |
|
V56387 | anti-TNBC agent-2 | 2422001-22-5 | anti-TNBC agent-2 (3j) is a purine analogue against triple-negative breast cancer (TNBC). |
|
V35002 | anti-TNBC agent-3 | 2422001-25-8 | anti-TNBC agent-3 (compound 3g) is an apoptosis inducer with anti-cancer cell proliferation/growth activity. |
|
V85522 | anti-TNBC agent-4 | 3027501-51-2 | |
|
V34835 | Antibiotic DC 81 (DC 81) | 81307-24-6 | Antibiotic DC 81 (DC 81) is an antitumor antibiotic produced by Streptomyces species and is a pyrrole[2,1-c][1,4]benzodiazepine (PBD). |
|
V34997 | Anticancer agent 102 | 2914922-86-2 | anti-cancer compound 102 is an analogue of tetracaine. |
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