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Reactive Oxygen Species

Reactive Oxygen Species

Reactive oxygen species (ROS) are radical and non-radical oxygen species produced by the partial reduction of oxygen, including superoxide anion (O2-), hydrogen peroxide (H2O2), and hydroxyl radical (HO•). Endogenous ROS are produced by cells during their normal oxidative metabolism in the mitochondria as well as when they react to xenobiotics, cytokines, and bacterial invasion.

By directly inhibiting MAPK phosphatases, ROS also activates MAPK pathways. Through PTEN, ROS produced by growth factor stimulation are capable of reversibly controlling the redox state of the PI3K pathway. The cellular response to ROS may involve the activation of autophagy.

Reactive Oxygen Species related products

Structure Cat No. Product Name CAS No. Product Description
Crocin-4 V72909 Crocin-4 55750-86-2 Crocin-4, a carotenoid, is a potent and BBB (blood-brain barrier) permeable (penetrable) antioxidant.
CycLuc1 V33429 CycLuc1 1247879-16-8 CycLuc1,a synthetic luciferase substrate, is a brain penetrant luciferase substrate which displays NIR emission.
CYPMPO V72907 CYPMPO 934182-09-9 CYPMPO is a spin trapping agent.
D-Isofloridoside V72915 D-Isofloridoside 23202-76-8 D-Isofloridoside is one of the polysaccharide precursors and has the activity of scavenging free radicals, inhibiting ROS expression, and inhibiting MMP-2 and MMP-9.
Danshenol A (danshenol A) V72946 Danshenol A (danshenol A) 189308-08-5 Danshenol A is a rosin diterpenoid and an aldose reductase (AR) inhibitor (antagonist) with IC50 of 0.1 μM.
Dehydrocurdione V72917 Dehydrocurdione 38230-32-9 Dehydrocurdione, a zedoary-derived sesquiterpene, induces heme oxygenase (HO)-1, an antioxidant enzyme, in RAW 264.7 macrophages.
DHODH-IN-26 V87374 DHODH-IN-26 DHODH-IN-26 (compound B2) is a mitochondrial-targeted DHODH inhibitor.
Dichlorofluorescein V90053 Dichlorofluorescein 2320-96-9 Dichlorofluorescein is a fluorescent dye used in many scientific experiments and applications.
Dihexyl phthalate V106557 Dihexyl phthalate 84-75-3 Diethyl phthalate is one of the commonly used phthalates in various plastics and consumer products.
Dihydromyristicin V72925 Dihydromyristicin 52811-28-6 Dihydromyristicin is a plant flavonoid with potent anti-inflammatory activities.
DIM-C-pPhtBu V104730 DIM-C-pPhtBu 94944-80-6 DIM-C-pPhtBu is an orally active ER stress activator.
Diquafosol V86717 Diquafosol 59985-21-6 Diquafosol (INS365 free base) is a potent P2Y2 agonist.
DMNQ V20134 DMNQ 6956-96-3 DMNQ is a redox cycling agent.
DMPO V72880 DMPO 3317-61-1 DMPO is a cell-penetrating/penetrable hydrophilic spin trap for superoxide detection.
DPPD-Q V106969 DPPD-Q 3421-08-7 DPPD-Q is an antioxidant, an oxidized derivative of the substituted p-phenylenediamine DPPD, found in tire wear particles and rubber crumbs, PM2.5 particulate matter (PM2.5), and sewage influent and effluent.
Efaproxiral-d6 (Efaproxiral-d6) V72933 Efaproxiral-d6 (Efaproxiral-d6) 1246815-16-6 Efaproxiral-d6 is the deuterated form of Efaproxiral.
EGFR-IN-119 V100261 EGFR-IN-119 EGFR-IN-119 (Compound 5l) is an inhibitor of EGFR with IC50 of 84.3 nM.
Euparin (Zelanin) V72929 Euparin (Zelanin) 532-48-9 Euparin is a monomer compound of benzofuran and a reactive oxygen species (ROS) inhibitor.
Exserohilone V91019 Exserohilone 99572-22-2 Exserohilone ((-)-Exserohilone) is a thiodiketopiperazine derivative that inhibits TNF-α-induced ROS generation and MMP-1 secretion.
Ferric citrate (Iron(III) citrate; Zerenex) V72882 Ferric citrate (Iron(III) citrate; Zerenex) 3522-50-7 Ferric citrate (Iron(III) citrate), an orally bioactive iron supplement, is a potent phosphate binder.
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