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Reactive Oxygen Species

Reactive Oxygen Species

Reactive oxygen species (ROS) are radical and non-radical oxygen species produced by the partial reduction of oxygen, including superoxide anion (O2-), hydrogen peroxide (H2O2), and hydroxyl radical (HO•). Endogenous ROS are produced by cells during their normal oxidative metabolism in the mitochondria as well as when they react to xenobiotics, cytokines, and bacterial invasion.

By directly inhibiting MAPK phosphatases, ROS also activates MAPK pathways. Through PTEN, ROS produced by growth factor stimulation are capable of reversibly controlling the redox state of the PI3K pathway. The cellular response to ROS may involve the activation of autophagy.

Reactive Oxygen Species related products

Structure Cat No. Product Name CAS No. Product Description
Manganese(salen) chloride (EUK-8) V72897 Manganese(salen) chloride (EUK-8) 53177-12-1 Manganese(salen) chloride (EUK-8), a superoxide dismutase and catalase mimetic, is an antioxidant with oxygen free radical scavenging properties.
MAO-B-IN-7 V70696 MAO-B-IN-7 2851012-65-0 MAO-B-IN-7 is a potent and BBB (blood-brain barrier) permeable (penetrable) inhibitor of MAO-B and AChE, with IC50s of 41 nM, 87 nM and 0.3 μM for human AChE, electric eel AChE and MAO-B, respectively.
MAOS V72923 MAOS 82692-97-5 MAOS is an improved Trinder reagent that could be utilized as a chromogenic probe for the determination of H2O2.
Maresin 1 V72890 Maresin 1 1268720-28-0 Maresin 1 is a specific regulatory mediator of endogenous DHA production in the human body and can stimulate intracellular Ca2+ production and secretion.
Maritimetin V72918 Maritimetin 576-02-3 Maritimein is an orange ketone that can be extracted from alyssum.
MCB-613 V1884 MCB-613 1162656-22-5 MCB-613 is a novel and potent stimulator of p160 steroid receptor coactivators (SRCs).
MCI V80716 MCI MCI has a significant anti-inflammatory effect in collagen-induced arthritis (CIA) model by targeting the scavenging of reactive oxygen species (ROS) and down-regulating cyclooxygenase-2 (COX-2).
Mesotrione V72952 Mesotrione 104206-82-8 Mesotrione is a benzoylcyclohexanedione herbicide.
Mesuol V72936 Mesuol 16981-20-7 Mesuol is a naturally occurring compound extracted from M.
Methoxy-PMS V29766 Methoxy-PMS 65162-13-2 Methoxy-PMS (1-Methoxy PMS) is a stable electron transport intermediary.
Methyl aminolevulinate HCl (LS-187769) V5169 Methyl aminolevulinate HCl (LS-187769) 79416-27-6 Methyl-5-aminolevulinate HCl, a prodrug that is metabolised to Protoporphyrin IX (sensitizer) used in photodynamic therapy, is a used as a topical cream formulation which contains the hydrochloride salt of methyl-5-aminolevulinate, a lipophilic methyl ester of 5-aminolevulinic acid, with photosensitizer prodrug activity.
Methylophiopogonone B (Methylophiopogonone B) V72905 Methylophiopogonone B (Methylophiopogonone B) 74805-89-3 Methylophiopogonone B is an isoflavone extracted from Ophiopogonis Tiber that scavenges •OH and H2O2.
Moslosooflavone V34285 Moslosooflavone 3570-62-5 Moslosooflavoneone is a natural flavonoid extracted from Andrographis paniculata.
MSU38225 V72942 MSU38225 1629160-83-3 MSU38225 is an Nrf-2 inhibitor that increases reactive oxygen species (ROS) levels.
N,N'-Dimethylthiourea (N,N-dimethylthiourea; DMTU) V72884 N,N'-Dimethylthiourea (N,N-dimethylthiourea; DMTU) 534-13-4 N,N'-Dimethylthiourea (DMTU), extracted from black garlic, is an orally bioavailable and effective scavenger of hydroxyl radicals (•OH), preventing the production of •OH in vitro by activated neutrophils.
N-Acetyl-D-cysteine V72883 N-Acetyl-D-cysteine 26117-28-2 N-Acetyl-D-cysteine has anti-oxidant effect and scavenges ROS by reacting with sulfhydryl groups, but it cannot enter the glutathione metabolic pathway.
N-Acetyl-L-cysteine ethyl ester (N-Acetylcysteine ethyl ester; NACET) V72879 N-Acetyl-L-cysteine ethyl ester (N-Acetylcysteine ethyl ester; NACET) 59587-09-6 N-Acetyl-L-cysteine ethyl ester is the esterified form of NAC.
N-Acetyldopamine dimer-2 V72920 N-Acetyldopamine dimer-2 916888-49-8 N-Acetyldopamine dimer-2 (compound 2) is an N-acetyldopamine dimer with antioxidant and anti-inflammatory activity that can be extracted from the yellow powder of cicada bark.
N-tert-Butyl-α-phenylnitrone V72889 N-tert-Butyl-α-phenylnitrone 3376-24-7 N-tert-Butyl-α-phenylnitrone is a nitrone-based free radical scavenger that forms nitric oxide spin adducts.
N-tert-Butyl-α-phenylnitrone-d14 (N-tert-butyl-α-phenylnitrone-d14) V72972 N-tert-Butyl-α-phenylnitrone-d14 (N-tert-butyl-α-phenylnitrone-d14) 119391-92-3 N-tert-Butyl-α-phenylnitrone-d14 is the deuterium labelled form of N-tert-Butyl-α-phenylnitrone.
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