Histone Demethylase

ADC Related

ADC Antibody ADC Cytotoxin ADC Linker ADCs Drug-Linker Conjugates for ADC
Angiogenesis

5-alpha Reductase ALK Bcr-Abl BTK EGFR FAK FLT3 HER-2 HIF Src Syk VDA VEGFR
Anti-infection

Antibiotic Arenavirus Bacterial CMV EBV Enterovirus Filovirus Fungal Gli HBV HCV HCV Protease HIV HSV Influenza Virus Parasite RABV Reverse Transcriptase RSV SARS-CoV TMV Virus Protease
Apoptosis

Apoptosis ASK Bcl-2 Caspase c-Myc c-RET Cytohesin DAPK Ferroptosis FKBP IAP Mdm2 p53 PD-1 PD-L1 PERK PKD Ras RIP kinase ROS Survivin Thymidylate Synthase TNF Receptor TNFa TRADD
Autophagy

Autophagy LRRK2 Mitophagy OGA ULK
Cell Cycle

Antifolate APC Aurora Kinase BMI-1 CDK Chk c-Myc Eukaryotic Initiation Factor G-quadruplex HDAC HSP Kinesin LIMK Mad2 Microtubule(Tubulin) Mps1 Nucleoside Antimetabolite/Analog Nur77 p21 PAK PERK PFKFB PLK PPAR Ras Rho ROCK SRPK TOPK Topoisomerase Wee1
Cytoskeletal Signaling

Arp2 3 Complex Bcr-Abl Cardiac Myosin Dynamin Gap Junction Protein HSP Integrin Kinesin Microtubule Associated MLCK Myosin PAK TACC3 Wntbeta-catenin
DNA Damage

ATM(ATR) CRISPR(Cas9) DNA alkylator DNA Stain DNA(RNA) Synthesis GAK HDAC HSP Nucleoside Antimetabolite(Analog) OGG1 p97 PARG PARP RAD51 RNR Sirtuin SMN Telomerase Topoisomerase
Endocrinology & Hormones

5-alpha Reductase ACE Adrenergic Receptor Androgen Receptor Aromatase Estrogenprogestogen Receptor Glucocorticoid Receptor GPR Mineralocorticoid Receptor RAAS THR TSH Receptor
Epigenetics

AMPK Aurora Kinase DNA Methyltransferase Epigenetic Reader Domain EZH1 2 HDAC HIF Histone Acetyltransferase Histone Demethylase Histone Methyltransferase JAK MAT MicroRNA MLL Pim PKC Protein Arginine Deiminase Sirtuin Small Interfering RNA (siRNA) SMYD

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Histone Demethylase

Histone methylation is carried out by methyltransferases and demethylases, two classes of enzymes. While methyltransferases are in charge of creating methylation patterns, demethylases have the ability to remove methyl groups from proteins other than histones. Histone demethylases interact with methylated sites on non-histone proteins, such as p53, in addition to targeting methylated sites on histone tails.
Due to their regulatory functions in chromatin organization and their close ties to diseases like cancer and mental disorders, histone lysine demethylases (KDMs) are of interest as drug targets.

Demethylase JMJD1A, also known as KDM3A, eliminates methyl from histone lysine H3K9. It is crucial for many cellular functions, such as spermatogenesis, energy metabolism, stem cell control, and gender expression.

A histone demethylase known as Jumonji domain-containing 3 (Jmjd3) has been discovered, and it specifically catalyzes the removal of methylation from H3K27me3.

Histone Demethylase related products

Cat No.	Product Name	CAS No.	Product Description
V56074	(1R,2S)-NCD38 TFA	2078047-42-2	(1R,2S)-NCD38 TFA is an enantiomer of NCD38 TFA.
V3597	GSK2879552	1401966-69-5	GSK2879552 (GSK-2879552) is a novel, potent and orally bioavailable, irreversible inhibitor oflysine specific demethylase 1 (LSD1)with potential anticancer activity.
V0372	IOX1	5852-78-8	IOX1 (5-Carboxy-8-hydroxyquinoline) is a novel, potent and broad-spectrum inhibitor of 2OG oxygenases (e.
V94227	Acaricide		The acaricide (compound 7l) is a potent LSD1 inhibitor.
V52401	Arborinine	5489-57-6	Arborinine is a potent orally bioactive LSD1 inhibitor.
V2982	AS8351	796-42-9	AS8351 is a potent inhibitor of KDM5B (lysine-specific histone demethylase 5B) which plays an important role in maintaining cancer stem cells and justifies the rationale for studying the effects of continuous inhibition of this epigenetic factor in cancer.
V94215	Bizine di(hydrochloride)	1808112-57-3	Bizine dihydrochloride, a phenelzine analog, is a potent and selective LSD1 inhibitor with a Ki value of 59 nM.
V77191	Bomedemstat dihydrochloride (IMG-7289 dihydrochloride)		Bomedemstat (IMG-7289) di-HCl is an orally bioactive and irreversible inhibitor of lysine-specific demethylase 1 (LSD1).
V56076	CBB1003 hydrochloride	2070015-02-8	CBB1003 HCl is an inhibitor (blocker/antagonist) of histone demethylase LSD1 with IC50 of 10.54uM.
V17664	CBB1007	1379573-92-8	CBB1007 can penetrate cells and is a selective inhibitor of hLSD1 with IC50 of 5.27 μM.
V56067	CBB1007 hydrochloride	2070014-96-7	CBB1007 HCl is a highly efficient substrate competitive, reversible, and selective inhibitor of the histone demethylase LSD1, with IC50 of 5.27 uM for hLSD1.
V52955	CBB1007 trihydrochloride	2070015-03-9	CBB1007 triHCl is a selective inhibitor of LSD1 with IC50 of 5.27uM.
V75857	cis-4-Br-2,5-F2-PCPA (S1024)	2821068-03-3	cis-4-Br-2,5-F2-PCPA (S1024) is a selective inhibitor of lysine-specific demethylase 1 (LSD1) with a Ki of 94 nM and a Ki of 8.4 for LSD2 μM.
V2606	CPI-455	1628208-23-0	CPI-455 is a novel, potent andspecific inhibitor of the KDM5demethylase which catalyzes the demethylation of histone H3 on lysine 4 (H3K4) and is required for the survival of drug-tolerant persister cancer cells (DTPs).
V10836	CPI-455 hydrochloride	2095432-28-1	CPI-455 HCl is a specific pan-KDM5 inhibitor (antagonist) with IC50 of 10 nM for KDM5A.
V2936	DDP-38003 dihydrochloride	1831167-98-6	DDP-38003 dihydrochloride, atranylcypromine (TCPA) derivative, is a novel, potent and orally bioavailable inhibitor of histone lysine-specific demethylase 1A (KDM1A/LSD1).
V77096	DDP-38003 trihydrochloride		DDP-38003 triHCl is a novel, orally bioactive KDM1A/LSD1 inhibitor (antagonist) with IC50 of 84 nM.
V56182	Eicosapentaenoic Acid-d5 (EPA-d5; Timnodonic acid-d5)	1197205-73-4	Eicosapentaenoic Acid-d5 is the deuterium labelled form of Eicosapentaenoic Acid.
V80080	FY-21		FY-21 is a selective LSD1 inhibitor (IC50=340 nM) with antiproliferation and anti-colony-forming activities.
V52030	GSK 690 Hydrochloride	2436760-79-9	GSK 690 ( HCl) is a reversible inhibitor of lysine-specific demethylase 1 (LSD1) with a Kd of 9 nM and IC50 of 37 nM.