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PI3K

PI3K

PI3K (Phosphoinositide 3-kinase), via phosphorylation of the inositol lipid phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2), forms the second messenger molecule phosphatidylinositol (3,4,5)-trisphosphate (PI(3,4,5)P3) which recruits and activates pleckstrin homology domain containing proteins, leading to downstream signalling events crucial for proliferation, survival and migration. The four distinct catalytic isoforms of class I PI3K enzymes are PI3K, PI3K, PI3K, and PI3K.
Three main classes of PI3K enzymes exist, with class IA being strongly linked to cancer. Catalytic subunits (p110α, p110β, or p110δ; encoded by PIK3CA, PIK3CB, and PIK3CD genes, respectively) and regulatory subunits (p85) make up heterodimeric lipid kinases known as class IA PI3K.

The PI3K pathway is crucial for the progression of the cell cycle, cell growth and survival, actin rearrangement and migration, and intracellular vesicular transport, among many other biological processes.

PI3K related products

Structure Cat No. Product Name CAS No. Product Description
α-Linolenic acid-13C18 (α-linolenic acid 13C18) V69237 α-Linolenic acid-13C18 (α-linolenic acid 13C18) 287111-28-8 α-Linolenic acid-13C18 is 13C (carbon 13) labelled α-Linolenic acid.
α-Linolenic acid-d14 (α-linolenic acid d14) V69230 α-Linolenic acid-d14 (α-linolenic acid d14) 1622944-40-4 α-Linolenic acid-d14 is the deuterated form of α-Linolenic acid.
α-Linolenic acid-d5 (α-linolenic acid d5) V69219 α-Linolenic acid-d5 (α-linolenic acid d5) 145191-04-4 α-Linolenic acid-d5 is the deuterated form of α-Linolenic acid.
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