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NF-κB

NF-κB

Nuclear factor-κB (NF-κB)/Rel proteins include NF-κB2 p52/p100, NF-κB1 p50/p105, c-Rel, RelA/p65, and RelB.These proteins perform as two-component transcription factors that control gene expression and have an impact on a variety of biological processes, such as innate and acquired immunity, inflammation, stress responses, B-cell development, and lymphoid organogenesis.The immune system's reaction to infection is significantly regulated by NF-B. In addition, the etiology of chronic inflammatory illnesses such inflammatory bowel disease, rheumatoid arthritis, and asthma is influenced by the activation of the NF-B pathway. Septic shock, autoimmune and inflammatory disorders, viral infections, and poor immunological development have all been connected to faulty NF-B regulation.

NF-κB related products

Structure Cat No. Product Name CAS No. Product Description
S217879 V78377 S217879 S217879 is a highly efficient and selective NRF2 activator.
SC75741 V0769 SC75741 913822-46-5 SC75741 (SC-75741; SC 75741) is a novel,selective and potent NF-κB inhibitor with potential antiviral and anti-inflammatory activity.
Schisantherin A V14531 Schisantherin A 58546-56-8 Schisantherin A is a lignan.
Selenocystine V82292 Selenocystine 2897-21-4 Selenocystine is a broad-spectrum anticancer agent.
Siegesbeckialide I V79845 Siegesbeckialide I Siegesbeckialide I potently inhibits LPS-induced NO production in RAW264.7 cells by directly binding to IKKα/β.
Sinomenine V40026 Sinomenine 115-53-7 Sinomenine, a naturally occuringalkaloid isolated from the root of the plant Sinomenium acutum, is a blocker of the NF-κB activation with anticancer and anti-inflammatory effects.
Sinomenine hydrochloride (Cucoline) V29937 Sinomenine hydrochloride (Cucoline) 6080-33-7 Sinomenine HCl (Cucoline), the hydrochloride salt of Sinomenine, is a naturally occuringalkaloid isolated from the root of the plant Sinomenium acutum.
SM-7368 V14936 SM-7368 380623-76-7 SM-7368 is an NF-kB inhibitor that targets the downstream MAPK p38.
Sodium 4-Aminosalicylate V0764 Sodium 4-Aminosalicylate 6018-19-5 Sodium 4-Aminosalicylate,the sodium salt of aminosalicylic acid and an analog of PABA/para-aminobenzoic acid,is an antibiotic used to treat MDR-TB/multidrug-resistant tuberculosis via NF-κB inhibition and free radical scavenging.
Sodium salicylate V0767 Sodium salicylate 54-21-7 Sodium salicylate (Magsalyl;Kerasalicyl; Kerosal), thesodium salt of salicylic acid and a metabolite of acetylsalicylic acid, is an inhibitor of NF-kB with potential anti-inflammatory activity.
Sphingosine-1-phosphate (S1P) V82282 Sphingosine-1-phosphate (S1P) 26993-30-6 Sphingosine-1-phosphate (S1P) is an agonist of S1P1-5 receptors and a ligand of GPR3, GPR6, and GPR12.
Sulfasalazine (NSC 667219) V5108 Sulfasalazine (NSC 667219) 599-79-1 Sulfasalazine (NSC-667219) is an approved antiinflammatory drug used for the treatment of rheumatoid arthritis, inflammatory bowel disease such as including ulcerative colitis and Crohns disease.
TAT-14 TFA V81517 TAT-14 TFA TAT-14 TFA is a 14-mer peptide that works as an Nrf2 activator.
TBK1/IKKε-IN-3 V84640 TBK1/IKKε-IN-3 851814-28-3
Tectochrysin V30311 Tectochrysin 520-28-5 Tectochrysin (Techtochrysin) is one of the major flavonoids of Alpinia oxyphylla.
Terpendole I V82291 Terpendole I 167612-17-1 Terpendole I is a fungal indole diterpene and an ACAT inhibitor (IC50=145 µM).
Thalidomide-O-amido-PEG2-C2-NH2 (Cereblon Ligand-Linker Conjugates 10; E3 Ligase Ligand-Linker Conjugates 24) V82257 Thalidomide-O-amido-PEG2-C2-NH2 (Cereblon Ligand-Linker Conjugates 10; E3 Ligase Ligand-Linker Conjugates 24) 1957235-74-3 Thalidomide-O-amido-PEG2-C2-NH2 combines an E3 ligase ligand and a linker to study cancer as an immunomodulator.
TML-6 V70236 TML-6 1462868-88-7 TML-6 is an orally bioavailable curcumin analogue that can inhibit the synthesis of β-amyloid precursor protein and β-amyloid (Aβ).
Tonlamarsen sodium (ION-904 sodium) V82285 Tonlamarsen sodium (ION-904 sodium) 2589926-21-4 Tonlamarsen sodium is an angiotensinogen synthesis reducing agent with anti-hypertensive (blood pressure lowering) activity.
Triptolide (PG490) V2079 Triptolide (PG490) 38748-32-2 Triptolide (also known as NSC 163062), a diterpene triepoxide, is an immunosuppresive agent extracted from the Chinese herb Tripterygium wilfordii.
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