Cell membrane blebbing, chromatin condensation, genomic DNA fragmentation, and the exposure of particular phagocytosis signaling molecules on the cell surface are just a few of the distinctive morphological and biochemical features of the cell death process known as apoptosis. Apoptosis-initiated cell death is distinct from necrosis-induced cell death. Apoptotic death, in contrast, is silent and orderly. Necrotic cells are typically recognized as a danger signal by the immune system, which causes inflammation.
There are two main methods for inducing apoptotic cell death: The intrinsic pathway, also known as the Bcl-2-regulated or mitochondrial pathway, is strictly regulated by the BCL-2 family of proteins and is activated by a variety of developmental cues or cytotoxic insults, such as viral infection, DNA damage, and growth-factor deprivation.The tumor necrosis factor (TNF) receptor family members, such as Fas or TNF receptor-1 (TNFR1), which contain an intracellular death domain and can recruit and activate caspase-8 through the adaptor protein Fas-associated death domain (FADD; also known as MORT1) at the cell surface, are what initiate the extrinsic or death-receptor pathway. Without the involvement of the BCL-2 family, this recruitment results in the subsequent activation of downstream (effector) caspases like caspase-3, -6, or -7.
Numerous human diseases, including cancer, viral infections, autoimmune diseases, neurodegenerative disorders, and AIDS (acquired immunodeficiency syndrome), may be influenced by changes in cell survival, according to studies. Some of these diseases may not progress naturally unless specific therapies that change the apoptotic threshold are used.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
|
V52399 | Argipressin acetate (Arg8-vasopressin acetate; AVP acetate) | 129979-57-3 | Argipressin (Arg8-vasopressin) (acetate) binds to vasoarginine vasopressin receptors V1, V2, and V3, with a Kd of 1.31 nM for V1 in A7r5 rat aortic smooth muscle cells. |
|
V52398 | ARN14494 | 1037837-27-6 | ARN14494 is a potent and specific serine palmitoyltransferase (SPT) inhibitor (antagonist) with IC50 of 27.3 nM. |
|
V8035 | Aromadedrin (Dihydrokaempferol) | 480-20-6 | Aromadedrin, isolated fromBauhinia championii(Benth),also known asDihydrokaempferol, is a novel and potent inhibitor of protein kinase C. |
|
V56269 | Artemisinin-d3 (Qinghaosu-d3; NSC 369397-d3) | 176652-07-6 | Artemisinin-d3 is the deuterated form of Artemisinin. |
|
V52587 | Artesunate-d3 (artemisinate d3) | 1316303-44-2 | Artesunate-d3 is the deuterium labelled form of Artesunate. |
|
V52391 | AS-99 free base | 2323623-93-2 | AS-99 is a first-in-class, potent and specific ASH1L histone methyltransferase inhibitor (IC50= 0.79 µM, Kd= 0.89 µM) with anti-leukemia activity. |
|
V52389 | ASK1-IN-2 | 2541792-70-3 | ASK1-IN-2 is a potent, orally bioactive inhibitor of apoptosis signal-regulated kinase 1 (ASK1) with IC50 of 32.8 nM. |
|
V54902 | ASK1-IN-4 | 1427538-26-8 | ASK1-IN-4 (Compound 17) is an ASK1 inhibitor (IC50=0.2 μM). |
|
V54874 | Asparanin A | 84633-33-0 | Asparanin A is an apoptosis inducer with anti-cancer activity. |
|
V52386 | Aspidin BB | 584-28-1 | Aspidin BB is a phloroglucinol analogue extracted from the aerial parts of Dryopteris championii. |
|
V52385 | ASR-488 | 2690312-65-1 | ASR-488 can activate the mRNA binding protein CPEB1, cause apoptosis and inhibit the growth of bladder cancer. |
|
V52384 | Astin B | 151201-76-2 | Astin B is an orally bioavailable cyclic pentapeptide extracted from Aster tataricus. |
|
V7932 | Astragalin | 480-10-4 | Astragalin is a novel and potent flavonoid. |
|
V52381 | Asunercept (APG101; CAN008) | 1450882-18-4 | Asunercept (APG101; CAN008) is a soluble CD95-Fc fusion protein targeting CD95L. |
|
V83568 | ATPase-IN-3 | 1134203-12-5 | |
|
V29493 | Atractylenolide III | 73030-71-4 | Atractylenolide III (ICodonolactone) is the major component of Atractylodes rhizome and has the activity of inducing apoptosis in lung cancer/tumor cells. |
|
V54841 | Atrosab | 1365659-05-7 | Atrosab is a humanized IgG1 antagonist anti-TNFR1 antibody. |
|
V52372 | AV123 | 233605-81-7 | AV123 (Compound 12) is a non-cytotoxic RIPK1 inhibitor (IC50=12.12 µM). |
|
V84748 | Axl-IN-18 | ||
|
V84746 | Azalamellarin N (AZL-N) | 1809535-57-6 |
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