An important part of apoptosis (programmed cell death), necrosis, and inflammation is played by the cysteine protease family known as caspase. Apoptotic caspases come in two varieties: effector (executioner) caspases and initiator (apical) caspases. Effector caspases are activated when initiator caspases, such as CASP2, CASP8, CASP9, and CASP10, cleave their inactive pro-forms. In order to start the apoptotic process, effector caspases (such as CASP3, CASP6, and CASP7) cleave other protein substrates inside the cell. Caspase inhibitors control how this cascade reaction gets started. Because they are inflammatory enzymes that cooperate with CASP1 to play a role in T-cell maturation, CASP4 and CASP5, which are overexpressed in some cases of vitiligo and related autoimmune diseases brought on by NALP1 variants, are not currently classified as initiators or effectors in MeSH.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
|
V16094 | Terfenadine | 50679-08-8 | Terfenadine (BRN5857899; Seldane; Terfen) is a novel and potent antihistamine drug used totreat allergies. |
|
V23841 | Wedelolactone | 524-12-9 | Wedelolactone (IKK Inhibitor II) is a naturally occuring coumarin ether with potent hepatoprotective activities. |
|
V76000 | Z-Ala-Ala-Asp-CMK (Z-AAD-CMK) | 183284-21-1 | Z-Ala-Ala-Asp-CMK (Z-AAD-CMK) is a selective granzyme B inhibitor. |
|
V0029 | Z-DEVD-FMK | 210344-95-9 | Z-DEVD-FMK, atetrapeptide compound, is a novel, potent,specific, cell-permeable and irreversiblecaspase-3 inhibitorwithIC50of 18 μM. |
|
V0030 | Z-IETD-FMK | 210344-98-2 | Z-IETD-FMK (also known as Z-IE(OMe)TD(OMe)-FMK) is a novel, specific, selective,irreversible and cell permeableCaspase-8/9 inhibitor. |
|
V76001 | Z-IETD-pNA (Z-Ile-Glu-Thr-Asp-pNA) | 348079-18-5 | Z-IETD-pNA (Z-Ile-Glu-Thr-Asp-pNA) is a colorimetric caspase-8 and granzyme B substrate. |
|
V4117 | Z-LEHD-FMK | 210345-04-3 | Z-LEHD-FMK is a cell-permeable, specific, competitive and irreversible inhibitor of enzyme caspase-9, which helps in cell survival andprotects against lethal reperfusion injury and attenuates apoptosis. |
|
V0032 | Z-VAD(OH)-FMK (Caspase Inhibitor VI) | 161401-82-7 | Z-VAD-FMK (Caspase Inhibitor VI; Z-VAD(OH)-FMK)is a novel, potent and irreversible pan caspase inhibitor. |
|
V0028 | Z-VAD-FMK | 187389-52-2 | Z-VAD-FMK (Z-VAD(OMe)-FMK; Z-Val-Ala-Asp(OMe)-FMK), a peptide compound,is a novel, potent cell-permeable and irreversible (covalent) inhibitor ofpan-caspase. |
|
V75999 | Z-YVAD-pNA (Z-Tyr-Val-Ala-Asp-pNA) | 154564-23-5 | Z-YVAD-pNA (Z-Tyr-Val-Ala-Asp-pNA) is a caspase-1 substrate. |
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