Cytochrome p450 comprises a superfamily of heme-thiolate proteins named for the spectral absorbance peak of their carbon-monoxide-bound species at 450 nm. The p450 superfamily, which has members in every class of organisms, including Archaea, is thought to have descended from an ancestor gene that existed more than 3 billion years ago. One of the biggest multigene families has subsequently been created as a result of repeated gene duplications. These enzymes stand out for the variety of reactions they catalyze as well as the variety of chemically diverse substrates they act on.The oxidative, peroxidative, and reductive metabolism of endogenous and exogenous substrates like environmental toxins, agrochemicals, plant allelochemicals, steroids, prostaglandins, and fatty acids is supported by cytochrome p450s. Drug interactions and interindividual variability in drug metabolism are two of the most important issues in clinical pharmacology, and cytochrome p450s in humans are best known for their central role in phase I drug metabolism.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V2226 | DMU-2105(CYP1B1 inhibitor 7k) | 1031063-36-1 | DMU-2105(CYP1B1 inhibitor 7k), is a novel,potent and selective CYP1B1 inhibitor with IC50s of 10 nM and 742 nM for CYP1B1 and CYP1A1, respectively. |
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V4600 | Orteronel (racemic) | 426219-18-3 | Orteronel racemate, the mixture of S-enantiomer and R-enantiomer of Orteronel (aslo known as TAK-700) which is a novel, potent and highly selective, orally bioavailable non-steroidal androgen synthesis inhibitor of human 17,20-lyase inhibitor with IC50 of 38 nM, it exhibits >1000-fold selectivity over other CYPs (e. |
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V0816 | PF-4981517 | 1390637-82-7 | PF-4981517 (also named as PF 04981517; PF04981517,CYP-3cide,PF 4981517;PF4981517) is a specific andtime-dependent inactivator of human CYP3A4(P450) with IC50 of 0.03 μM, it exhibits >500-fold selectivity for inhibiting CYP3A4 over CYP3A5 and CYP3A7 and a time-dependent inactivation of human CYP3A4. |
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V0819 | TAK-700/Orteronel (s-isomer) | 566939-85-3 | Orterone (aslo known as TAK-700; TAK 700;TAK700) is an orally bioavailable non-steroidal androgen synthesis inhibitor of human 17,20-lyase inhibitor with potential anticancer activity. |
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V0822 | Sodium Danshensu | 67920-52-9 | Sodium Danshensu (Danshensu Sodium), the sodium saltof danshensu, is a novel, potent,naturally occuring phenolic acid of caffeic acid derivatives isolated from Salvia miltiorrhiza with various biological activity (e. |
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V0801 | Abiraterone Acetate (Zytiga; formerly CB-7598; CB7598; CB 7598) | 154229-18-2 | Abiraterone Acetate (brand name Zytiga; formerly CB-7598; CB7598;CB 7598),the 3-acetylated and prodrug form of Abiraterone, is an irreversible and steroidal cytochrome CYP17 inhibitor with potential antitumor activity. |
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V0805 | Itraconazole | 84625-61-6 | Itraconazole (Orungal, Oriconazole, Sporanox,R51211;R-51211), a marketedtriazole-based antifungal drug since 1984, is a potent inhibitor of CYP3A4 that has been widely used for the treatment of fungal infections. |
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V0802 | Voriconazole | 137234-62-9 | Voriconazole (UK-109496; UK109496; trade name Vfend) is a 2nd-generation and potent triazole-based antifungal drug used for treating a variety of fungal infections. |
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V2872 | Ezutromid (BMN-195, SMTC-1100) | 945531-77-1 | Ezutromid (also known as BMN-195 and SMTC-1100) is a first-in-class, orally bioavailable,small molecule modulator of the utrophins translation with EC50 of 0.4 uM. |
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V0814 | Clarithromycin | 81103-11-9 | Clarithromycin (A56268; Abbott 56268; A 56268; Abbott-56268; A-56268; trade name Biaxin) is an approved macrolide antibiotic medication acting as a CYP3A4 inhibitor. |
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V0811 | Galeterone | 851983-85-2 | Galeterone (formerly known as NX 41765;TOK001;VN/124-1; NX-41765; VN-1241;TOK-001) is a novel, potent and selective, orally bioavailable CYP17 lyase inhibitor and androgen receptor (AR) antagonist with potential anticancer activity. |
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V0815 | Cobicistat (GS9350) | 1004316-88-4 | Cobicistat (trade name Tybost;Genvoya;GS-9350; GS 9350) is a novel, potent and selective inhibitor of CYP3A (cytochrome P450 3A) with IC50 of 30-285 nM. |
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V0820 | Pioglitazone HCl | 112529-15-4 | Pioglitazone HCl (also known as Actos;U-72107A;AD-4833; AD4833, U-72107E), the hydrochloride salt of Pioglitazone which is approved and thiazolidinedione-based anti-diabetic drug, is a selective PPARϒ agonist with hypoglycemic activity. |
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V0818 | Ozagrel | 82571-53-7 | Ozagrel (OKY046;KCT-0809;OKY046;Cataclot;KCT0809;Xanbo),an antiplatelet agent, is a potent and selective inhibitor of thromboxane A2 (TXA2 synthetase (IC50 = 11 nM) with antiplatelet activity. |
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V3877 | Stiripentol (BCX2600) | 49763-96-4 | Stiripentol (formerly known as BCX-2600; BCX2600;STP; trade name:Diacomit) is an FDA-approved anticonvulsant drug that inhibits the activity of several cytochromes P450 (P450s). |
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V13078 | Cedrol | 77-53-2 | Cedrol is a bioactive sesquiterpene and a potent competitive inhibitor of cytochrome P-450 (CYP) enzymes. |
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V0812 | Naringenin | 480-41-1 | Naringenin(S-Dihydrogenistein; Salipurol;NSC 11855; NSC-11855; NSC11855) is a naturally occuring flavanone extracted from plant food (e. |
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V0823 | Naringin | 10236-47-2 | Naringin (also known as Naringoside; AI319008;Aurantiin; AI3-19008), a flavanone-7-O-glycoside, is a novel, potent,natural flavanone glycoside found in citrus fruits (e. |
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V0806 | Fluconazole (UK49858) | 86386-73-4 | Fluconazole (Diflucan,UK-49858;UK 49858; Triflucan, Elazor, Biozolene) is a novel, potent, and orally bioavailable triazole-based antifungal drug that works by inhibiting fungal lanosterol 14 alpha-demethylase-dependent biosynthesis of ergosterol, which is an essential component of fungal cell membrane. |
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V0817 | Ozagrel HCl (OKY046 HCl; KCT0809; Cataclot) | 78712-43-3 | Ozagrel HCl(OKY-046 HCl;KCT 0809;Cataclot; Xanbo;OKY046 HCl), the hydrochloride salt of the antiplatelet drug Ozagrel, is a selective inhibitor of thromboxane A(2) (TXA(2)) synthetase (IC50 = 11 nM) with potential use for for the improving postoperative cerebrovascular contraction and accompanying cerebral ischaemia. |
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