Cell membrane blebbing, chromatin condensation, genomic DNA fragmentation, and the exposure of particular phagocytosis signaling molecules on the cell surface are just a few of the distinctive morphological and biochemical features of the cell death process known as apoptosis. Apoptosis-initiated cell death is distinct from necrosis-induced cell death. Apoptotic death, in contrast, is silent and orderly. Necrotic cells are typically recognized as a danger signal by the immune system, which causes inflammation.
There are two main methods for inducing apoptotic cell death: The intrinsic pathway, also known as the Bcl-2-regulated or mitochondrial pathway, is strictly regulated by the BCL-2 family of proteins and is activated by a variety of developmental cues or cytotoxic insults, such as viral infection, DNA damage, and growth-factor deprivation.The tumor necrosis factor (TNF) receptor family members, such as Fas or TNF receptor-1 (TNFR1), which contain an intracellular death domain and can recruit and activate caspase-8 through the adaptor protein Fas-associated death domain (FADD; also known as MORT1) at the cell surface, are what initiate the extrinsic or death-receptor pathway. Without the involvement of the BCL-2 family, this recruitment results in the subsequent activation of downstream (effector) caspases like caspase-3, -6, or -7.
Numerous human diseases, including cancer, viral infections, autoimmune diseases, neurodegenerative disorders, and AIDS (acquired immunodeficiency syndrome), may be influenced by changes in cell survival, according to studies. Some of these diseases may not progress naturally unless specific therapies that change the apoptotic threshold are used.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
|
V56461 | Moracin N | 135248-05-4 | Moracin N is a ferroptosis inhibitor that can be extracted from mulberry leaves. |
|
V41174 | MPP hydrochloride | 2863676-89-3 | MPP HCl is a potent and specific ER (estrogen receptor) modulator. |
|
V41172 | Mps1-IN-5 | 2890819-31-3 | Mps1-IN-5 is a potent, orally bioactive Mps1 inhibitor (antagonist) with IC50 of 29 nM. |
|
V41171 | MPT0B014 (6-(3′,4′,5′-Trimethoxybenzoyl)quinoline) | 1215208-59-5 | MPT0B014 is a tubulin polymerization inhibitor. |
|
V41168 | MRIA9 | 2750707-05-0 | MRIA9 is an ATP-competitive, pan-SIK and PAK2/3 inhibitor (antagonist) with IC50s of 516 nM, 180 nM and 127 nM for SIK1, SIK2 and SIK3 respectively. |
|
V54863 | MTP | 2377372-62-6 | MTP is a PKM2 inhibitor. |
|
V41154 | MTX-23 (PROTAC AR-V7 degrader-2) | 2488296-74-6 | MTX-23 is an AR-based PROTAC. |
|
V55010 | Mumefural | 222973-44-6 | Mumefural is a bioactive component of the processed fruit of Prunus mume Sieb. |
|
V52426 | Murizatoclax (AMG 397) | 2245848-05-7 | Murizatoclax (AMG 397) is a specific and orally bioactive myeloid leukemia 1 (MCL-1) inhibitor (antagonist) with a Ki of 15 pM. |
|
V54891 | MY-673 | 2944459-96-3 | MY-673 is a colchicine binding site inhibitor (CBSI) that can inhibit tubulin polymerization. |
|
V41144 | MYC-IN-2 | 2244979-61-9 | MYC-IN-2 is a MYC protein-protein inhibitor. |
|
V52600 | Mycophenolate Mofetil-d4 (Mycophenolate Mofetil-d4) | 1132748-21-0 | Mycophenolate Mofetil-d4 is the deuterium labelled form of Mycophenolate Mofetil. |
|
V8390 | Mycophenolic acid (Mycophenolate) | 24280-93-1 | Mycophenolic acid (Mycophenolate) is an approved immunosuppressant drug used for preventing rejection in organ transplantation. |
|
V54484 | Mytoxin B | 105049-15-8 | Mytoxin B is an ADC cytotoxin. |
|
V54848 | n-Octyl caffeate | 478392-41-5 | n-Octyl caffeate has anti-cancer and apoptosis-inducing activities. |
|
V56418 | N-Oleoyl-L-serine | 107743-37-3 | N-Oleoyl-L-Serine is an endogenous long-chain fatty acid amide with ethanolamine (n-acyl amide). |
|
V56394 | N-Oxide Lidocaine-d10 (Lidocaine d10 (N-oxide)) | 851528-10-4 | N-Oxide Lidocaine-d10 is the deuterium labelled form of Lidocaine. |
|
V85387 | N6F11 | 851398-76-0 | |
|
V2276 | NAE-IN-M22 | 864420-54-2 | NAE-IN-M22 is a potent, selective and reversible inhibitor of NEDD8 activating enzyme (NAE) with potency in the micromolar range. |
|
V53510 | Narasin sodium | 58331-17-2 | Narasin sodium is a cationic ionophore and anticoccidial agent. |
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