Heat shock proteins (HSPs) are a class of functionally related proteins that are involved in the folding and unfolding of other proteins. HSPs are a group of proteins that are produced in response to heat shock. When cells are subjected to high temperatures or other stresses, HSP expression rises. This increase in expression is controlled by transcription. Heat shock factor (HSF) is primarily responsible for the dramatic upregulation of the heat shock proteins, which is a crucial component of the heat shock response. Nearly every living thing, from bacteria to people, contains HSPs. Heat shock proteins seem to play a big part in the cardiovascular system. There have been reports of the roles of Hsp90, Hsp84, Hsp70, Hsp27, Hsp20, and alpha B crystallin in the cardiovasculature.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
|
V0877 | BIIB021 | 848695-25-0 | BIIB021 (CNF2024;BIIB-021; CNF-2024; CNF 2024; BIIB 021) is an orally bioavailable and purine-based small-molecule inhibitor of HSP90 (heat shock protein 90) with potential anticancer activity. |
|
V0883 | CH5138303 | 959763-06-5 | CH5138303 (CH 5138303; CH-5138303) is a novel, potent, orally boavailable HSP90 (Heat Shock Protein 90) inhibitor with potential anticancer activity. |
|
V0881 | HSP990 (NVP-HSP990) | 934343-74-5 | NVP-HSP990 (NVP HSP 990; NVP-HSP-990;HSP990; HSP-990) is an orally bioavailableHSP90 (heat shock protein 90) inhibitor with potential antitumor activity. |
|
V0880 | KNK437 | 218924-25-5 | KNK437 (KNK-437; KNK 437; Heat Shock Protein Inhibitor I), abenzylidene lactam analog, is a novel and potentpan-HSP (heat shock proteins) inhibitor with potential antineoplastic activity. |
|
V0889 | KW-2478 | 819812-04-9 | KW-2478 (KW 2478;KW2478) is a nonansamycin inhibitor of HSP90(Heat Shock Protein 90) with potential antitumor activity. |
|
V0884 | NMS-E973 | 1253584-84-7 | NMS-E973 (NMSE973; NMSE 973) is a novel, potent and selective HSP90 (Heat Shock Protein 90) inhibitor with potential antitumor activity. |
|
V5223 | NPX800 | 1693734-80-3 | NXP-800 (also known as CCT361814; CCT-361814) is a potentERK dimerization inhibitor andheat shock factor 1 (HSF1)inhibitor with anticancer effects. |
|
V0892 | NVP-BEP800 | 847559-80-2 | NVP-BEP800 (VER-82576; NVP BEP-800; BEP-800) is a novel, potent, fully synthetic, orally bioavailable heat shock protein 90β (HSP90β)inhibitor with potential antitumor activity. |
|
V0890 | PF-04929113 (SNX-5422) | 908115-27-5 | PF-04929113 (SNX-5422;PF04929113; PF-4929113) is a potent and selective inhibitor of heat shock protein 90 (HSP90) with potential antineoplastic activity. |
|
V0888 | SNX-2112 (PF-04928473) | 908112-43-6 | SNX-2112 (SNX2112; SNX 2112;PF-04928473; PF04928473)is a novel and potent HSP90(Heat Shock Protein 90) with potential antitumor activity and was inphase 1 clinical trials. |
|
V2769 | TRC051384 | 867164-40-7 | TRC051384 is a novel compoundwhich can potently induce HSPA1A/B (heat shock protein) expression and subsequent Hsp70 production via heat shock factor-1 (HSF1) activation. |
|
V0886 | VER-49009 | 558640-51-0 | VER-49009 (CCT0129397;VER 49009; CCT-0129397; VER49009), apyrazole-based compound,is a novel, potent and selective inhibitor of HSP90 (Heat Shock Protein 90) with potential antitumor activity. |
|
V0882 | VER-50589 | 747413-08-7 | VER-50589 (VER 50589; VER50589) is a highly potent and selectiveHSP90 (Heat Shock Protein 90) inhibitor with potential antineoplastic activity. |
|
V0879 | VER155008 | 1134156-31-2 | VER-155008 (VER 155008; VER155008) is an HSP70 (heat shock protein 70) inhibitor with anti-AD (alzheimers disease) effects. |
|
V0887 | XL888 | 1149705-71-4 | XL888 (XL-888; XL 888) is an orally bioavailable, ATP-competitive inhibitor of HSP90(Heat Shock Protein 90) with potential antitumor activity. |
|
V0876 | Elesclomol (STA-4783) | 488832-69-5 | Elesclomol (STA4783; STA-4783;STA4783) is a bis(thio-hydrazide amide)-basedheat shock protein 70/HSP70induceras well as anoxidative stress inducer with potential antitumor and pro-apoptotic activity. |
|
V0875 | Ganetespib (STA-9090) | 888216-25-9 | Ganetespib (formerly STA-9090; STA 9090; STA9090), the active metabolite of STA-1474 (a prodrug of ganetespib), is a potent and triazolone-based small-molecule HSP90 (heat shock protein 90) inhibitor with potential anticancer activity. |
|
V0872 | Tanespimycin (17-AAG) | 75747-14-7 | Tanespimycin (formerly NSC-330507; CP-127374; 17-AAG,BAY-579352,KOS-953,17-AAG,CP-127374),a benzoquinone analog and a derivative of the antibiotic geldanamycin,is an orally bioavailable and small-molecule inhibitor of heat shock protein 90/HSP90 with potential antitumor activity. |
|
V0878 | Onalespib (AT13387) | 912999-49-6 | Onalespib (formerly AT13387; AT-13387; AT 13387) is a novel, orally bioavailable,long-acting and isoindole-based small-molecule HSP90 (heat shock protein 90) inhibitor with potential antitumor activity. |
|
V0891 | Geldanamycin | 30562-34-6 | Geldanamycin (U-29135;NSC-122750; NSC122750; U 29135) isa natural occurring, benzoquinone-based ,19-membered macrocyle ansamycin class of anticancer antibiotic. |
Products are for research use only; We do not sell to patients
Copyright 2020 InvivoChem LLC | All Rights Reserved
